Table 1.
Enriched functions for the target genes of the downregulated miRNAs
| Terms | Count | P-value |
|---|---|---|
| Biological process (BP) | ||
| GO:0007049~cell cycle | 32 | 1.33E-07 |
| GO:0045893~positive regulation of transcription, DNA-templated | 55 | 2.23E-07 |
| GO:0000122~negative regulation of transcription from RNA polymerase II promoter | 69 | 3.35E-07 |
| GO:0000209~protein polyubiquitination | 28 | 4.95E-07 |
| GO:0006468~protein phosphorylation | 47 | 5.05E-06 |
| GO:0045944~positive regulation of transcription from RNA polymerase II promoter | 82 | 5.62E-06 |
| GO:0051301~cell division | 39 | 6.26E-06 |
| GO:0042787~protein ubiquitination involved in ubiquitin-dependent protein catabolic process | 23 | 7.78E-06 |
| GO:0006351~transcription, DNA-templated | 139 | 1.50E-05 |
| GO:0030879~mammary gland development | 8 | 4.83E-05 |
| Cellular component (CC) | ||
| GO:0005829~cytosol | 241 | 3.09E-12 |
| GO:0005737~cytoplasm | 341 | 1.53E-11 |
| GO:0005654~nucleoplasm | 204 | 1.61E-10 |
| GO:0005634~nucleus | 337 | 9.46E-09 |
| GO:0005874~microtubule | 33 | 4.18E-05 |
| GO:0035098~ESC/E (Z) complex | 7 | 6.33E-05 |
| GO:0048471~perinuclear region of cytoplasm | 53 | 6.82E-05 |
| GO:0043231~intracellular membrane-bounded organelle | 48 | 1.32E-04 |
| GO:0030496~midbody | 18 | 1.46E-04 |
| GO:0005794~Golgi apparatus | 66 | 2.07E-04 |
| Molecular function (MF) | ||
| GO:0005515~protein binding | 558 | 4.40E-18 |
| GO:0061630~ubiquitin protein ligase activity | 33 | 8.23E-10 |
| GO:0019901~protein kinase binding | 39 | 2.81E-05 |
| GO:0004842~ubiquitin-protein transferase activity | 34 | 1.07E-04 |
| GO:0044822~poly (A) RNA binding | 84 | 2.09E-04 |
| GO:0008270~zinc ion binding | 86 | 2.56E-04 |
| GO:0016874~ligase activity | 28 | 4.63E-04 |
| GO:0004672~protein kinase activity | 34 | 5.33E-04 |
| GO:0008536~Ran GTPase binding | 8 | 5.52E-04 |
| GO:0004674~protein serine/threonine kinase activity | 35 | 5.92E-04 |
| KEGG_PATHWAY | ||
| hsa04722: Neurotrophin signaling pathway | 22 | 1.53E-07 |
| hsa04151: PI3K-Akt signaling pathway | 39 | 7.09E-07 |
| hsa04068: FoxO signaling pathway | 22 | 1.04E-06 |
| hsa04510: Focal adhesion | 28 | 1.18E-06 |
| hsa04914: Progesterone-mediated oocyte maturation | 17 | 2.42E-06 |
| hsa04910: Insulin signaling pathway | 21 | 6.52E-06 |
| hsa05211: Renal cell carcinoma | 14 | 8.29E-06 |
| hsa04070: Phosphatidylinositol signaling system | 17 | 1.20E-05 |