Table 1.
Summary of patient population characteristics
| Characteristic | Total cohort (n = 82) | No event (n = 17) | With event (n = 65) | p-value (no event vs. with event) |
|---|---|---|---|---|
| Median age at diagnosis, years (range) | 4.1 (0.1–18.8) | 3.5 (1.0–18.8) | 4.2 (0.1–17.3) | 0.974 |
| Sex | 0.467 | |||
| Male | 45 (55%) | 8 (47%) | 37 (55%) | |
| Female | 37 (45%) | 9 (53%) | 28 (45%) | |
| Primary site | 0.070 | |||
| Infratentorial | 58 (71%) | 9 (53%) | 49 (75%) | |
| Supratentorial | 24 (29%) | 8 (47%) | 16 (25%) | |
| WHO grade | 0.416 | |||
| II | 26 (32%) | 4 (24%) | 22 (34%) | |
| III | 56 (68%) | 13 (76%) | 43 (66%) | |
| Follow-up time (year) | 0.157 | |||
| Median (range) | 4.6 (0.1–32.9) | 7.2 (0.1–32.9) | 4.5 (0.6–32.1) | |
| Management of primary tumor | ||||
| Surgery | 82 (99%) | 17 (100%) | 64 (98%) | 0.607 |
| Extent of resection | 0.184 | |||
| Gross total resection | 56 (68%) | 14 (82%) | 42 (65%) | |
| Subtotal resection | 25 (30%) | 3 (18%) | 22 (34%) | |
| Number of surgeries | 0.967 | |||
| ≤ 1 | 77 (94%) | 16 (94%) | 61 (94%) | |
| > 1 | 5 (6%) | 1 (6%) | 4 (6%) | |
| CSF diversion | 31 (38%) | 6 (35%) | 25 (38%) | 0.810 |
| Radiation | 57 (70%) | 12 (71%) | 45 (70%) | 0.914 |
| Median dose (range, Gy) | 55.8 (14.4–59.4) | 57.6 (50.0–59.4) | 55.8 (14.4–59.4) | 0.813 |
| Median duration of RT in days (range) | 44 (24–61) | 44 (39–51) | 44 (24–61) | 0.581 |
| Chemotherapy | 30 (37%) | 4 (24%) | 26 (40%) | 0.209 |
| Without RT | 19 (23%) | 3 (18%) | 16 (25%) | 0.578 |
| Pre-RT | 8 (10%) | 1 (6%) | 7 (11%) | |
| Post-RT | 3 (4%) | 0 (0%) | 3 (5%) | |
| Type of first event | ||||
| None | 17 (21%) | 17 (100%) | 0 (0%) | < 0.001 |
| Local failure | 41 (50%) | 0 (0%) | 41 (63%) | |
| Distant failure | 14 (17%) | 0 (0%) | 14 (22%) | |
| Local + distant failure | 6 (7%) | 0 (0%) | 6 (9%) | |
| Death | 4 (5%) | 0 (0%) | 4 (6%) | |
Event: relapse or death