Analysis of the protein expression after chronic meth self-administration in the (A) mPFC (B) dHPC and (C) PRh. (A,B,C - top insets): Representative immunoblotting results show the expression of 5-HT2A, mGlu2, Gαq/11, Gαi and Gαo proteins in saline and meth animals. Calnexin - control protein. (A, B, C - bar graphs): Quantitative analysis of the individual protein expression and of the calculated 5-HT2A/mGlu2 protein expression ratio. Data are expressed as the percentage of saline controls, n = 5-7 animals per group. (*p < 0.05, **p < 0.01 vs. yoked-saline controls). 2A/2 ratio - 5-HT2A/mGlu2 protein expression ratio.