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. 2019 Sep 23;14(9):e0222515. doi: 10.1371/journal.pone.0222515

Table 3. Differentially expressed mRNAs in corneal allografts and the related pathways.

Gene name Fold changes -log10(pvalue) Regulation Pathways
Col2a1 64.99649 3.659907 UP Platelet activation, Amoebiasis, ECM-receptor interaction, Focal adhesion,PI3K-Akt signaling pathway
Slamf1 54.33613 3.389823 UP Measles
Ccl5 32.64206 5.382971 UP Herpes simplex infection, Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Rheumatoid arthritis, Chagas disease (American trypanosomiasis), Prion diseases, Influenza A, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, TNF signaling pathway
Sytl3 25.03683 3.5796 UP --
Ctla4 24.49796 2.306209 UP Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Rheumatoid arthritis
Cxcl9 23.85567 6.415331 UP Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway
Cd247 16.43728 3.345338 UP T cell receptor signaling pathway, Natural killer cell mediated cytotoxicity, Chagas disease (American trypanosomiasis)
Tnfsf14 15.97684 1.804369 UP Herpes simplex infection, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway
Ptprc 15.70062 2.719765 UP Cell adhesion molecules (CAMs), T cell receptor signaling pathway, Primary immunodeficiency, Fc gamma R-mediated phagocytosis
Cd3d 14.05869 2.75214 UP T cell receptor signaling pathway, Primary immunodeficiency, Hematopoietic cell lineage, HTLV-I infection, Measles, Chagas disease (American trypanosomiasis)
FLOT2 11.6572 2.1253072 DOWN Insulin signaling pathway
Krt76 10.32507 1.3602218 DOWN --
Chrna5 10.32457 2.0483997 DOWN Neuroactive ligand-receptor interaction
Nkain1 9.861725 1.9800326 DOWN --
C2cd4c 7.978514 1.6805837 DOWN --
Piezo2 7.830693 1.495555 DOWN --
SH3BGR 7.510818 1.6031053 DOWN --
A930017K11Rik 7.509152 1.602825 DOWN --
Mrpl36 7.213453 2.2800434 DOWN Ribosome
Hspa8 2.295773 1.7078015 DOWN Antigen processing and presentation, Toxoplasmosis, Measles, Influenza A, Endocytosis, Epstein-Barr virus infection, Legionellosis, MAPK signaling pathway, Protein processing in endoplasmic reticulum, Estrogen signaling pathway, Spliceosome