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. 2019 Sep 18;14:2145–2162. doi: 10.2147/COPD.S216050

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© 2019 Lin et al.

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The SLIT2-ROBO signal pathway is downregulated in CS-induced emphysema mice model.

Notes: The relative mRNA expression of SLIT2 (A) ROBO2 (B) ROBO1 (C) Rac2 (D) and Cdc42 (E) in lungs of mice exposed to air or CS for 24 weeks. AIR-24W represents mice exposed to air for 24 weeks, and CS-24w represents mice exposed to CS for 24 weeks. ** p<0.01, ***p<0.001, ns: not significant.

Abbreviations: SLIT2, slit guidance ligand 2; ROBO, roundabout guidance receptor; CS, cigarette smoke; Rac2, Rac family small GTPase 2; Cdc42, cell division cycle 42.