Plot of competing outcomes by RVEDV/LVEDV ratio. Reprinted without changes from SAGE Publishing, Benza et al., Bosentan-based, treat-to-target therapy in patients with pulmonary arterial hypertension: results from the COMPASS-3 study, Pulmonary Circulation, Vol 8, Issue 1, DOI: https://doi.org/10.1177/2045893217741480, under the Creative Commons open access license agreement (CC BY 4.0) [40]