Table 1.
Prevalence of naturally occurring NS3 RASs in 86 HCV subtypes
| Sub-type | No. of seqa | V36 AGLM |
Q41 KR |
F43 CILSV |
T54 AS |
V55AI | Y56 FHN |
Q80 GHKLR |
|---|---|---|---|---|---|---|---|---|
| 1a | 7071, 7180 | 1.50L, 0.48M, 0.01A/G | 0.01R | 0.01L, 0.01S | 3.02S, 0.01A | 2.25A,1.82I | 0.67F,0.06H | 31.74K,1.14L,0.49R,0.01G,0.01H |
| 1b | 6849, 7133 | 0.96L, 0.03M, 0.01A | 0.04R,0.03K | 0.04L | 2.01S | 0.44A,021I | 26F | 3.68L,1.14K,0.30R,0.03H,0.01G |
| 1c | 5 | . | . | . | . | . | . | . |
| 1d | 15 | 13.33L | . | . | 66.7S | . | 6.67F | 86.67K |
| 1e | 15 | 100L | . | . | 100S | 6.67I | . | . |
| 1g | 5 | 20L | . | . | 80S | . | . | . |
| 1h | 6 | . | . | . | . | . | . | . |
| 1i | 6 | 16.67L | . | . | . | . | 16.7F | 16.67K |
| 1j | 1 | . | . | . | . | . | . | . |
| 1k | 1 | . | . | . | . | . | . | . |
| 1l | 9 | 22.22L | . | . | . | . | 11.1F | 77.8L |
| 1m | 2 | . | . | . | . | . | . | . |
| 1n | 2 | . | . | . | . | . | 50F | 50L |
| 2a | 53 | 98.11L | . | . | . | . | 3.77F | 98.1G,1.89Q |
| 2b | 111 | 100L | . | . | . | . | 3.6F | 100G |
| 2c | 9, 46 | 100L | . | . | . | . | 100F | 100G |
| 2d | 1 | 100L | . | . | . | . | 100F | 100G |
| 2e | 1 | 100L | . | . | 100A | . | 100F | 100G |
| 2f | 2 | 100L | . | . | . | . | 100F | 100G |
| 2i | 4 | 100L | . | . | . | . | 100F | 100G |
| 2j | 6 | 83.3L,16.7M | . | . | . | . | 100F | 100G |
| 2k | 4 | 75L | . | . | . | . | 75F | 75G |
| 2l | 4 | 100L | . | . | . | . | . | 100G |
| 2m | 4 | 100L | . | . | . | . | 100F | 100G |
| 2q | 2 | 100L | . | . | . | . | 100F | 100G |
| 2r | 1 | 100L | . | . | . | . | 100F | 100G |
| 2t | 1 | 100L | . | . | . | . | 100F | 100G |
| 2u | 1 | 100L | . | . | . | . | . | 100G |
| 3a | 780, 820 | 99.6L | . | . | 0.24S | 0.24I | 0.24F | 0.24K |
| 3b | 138 | 100L | . | . | 1.45S | . | . | . |
| 3d | 1 | 100L | . | . | . | . | . | . |
| 3e | 1 | 100L | . | . | . | . | . | . |
| 3g | 2 | 100L | . | . | . | . | . | . |
| 3h | 2 | 100L | . | . | . | . | . | . |
| 3i | 6 | 100L | . | . | . | . | . | 16.67R |
| 3k | 2 | 100L | . | . | . | . | . | . |
| 4a | 83, 92 | 97.8L | . | . | 6.52S | . | . | . |
| 4b | 2 | 100L | . | . | . | . | . | . |
| 4c | 1, 2 | 100L | . | . | . | . | . | . |
| 4d | 49, 69 | 100L | . | . | . | . | . | 1.45R |
| 4f | 11 | 100L | . | . | . | . | . | . |
| 4g | 3 | 100L | . | . | . | . | . | . |
| 4k | 4 | 100L | . | . | . | . | . | . |
| 4l | 3 | 100L | . | . | . | . | . | . |
| 4m | 4, 5 | 100L | . | . | . | . | . | . |
| 4n | 3, 4 | 100L | . | . | . | . | . | . |
| 4o | 4 | 100L | . | . | . | . | . | . |
| 4p | 1 | 100L | . | . | . | . | . | . |
| 4q | 1 | 100L | . | . | . | . | . | . |
| 4r | 6 | 100L | . | . | . | . | . | . |
| 4s | 1 | 100L | . | . | . | . | . | . |
| 4t | 1 | 100L | . | . | . | . | . | . |
| 4v | 4 | 100L | . | . | . | . | . | . |
| 4w | 2 | 100L | . | . | . | . | . | . |
| 5a | 46 | 100L | . | . | . | . | 100F | 100K |
| 6a | 409 | . | . | . | . | . | 0.73F | 98.28K,0.24L,0.24R |
| 6b | 2 | . | . | . | . | . | . | . |
| 6c | 2 | . | . | . | . | . | . | . |
| 6d | 1,2 | 50L | . | . | . | . | . | . |
| 6e | 10 | . | . | . | . | . | . | . |
| 6f | 22 | 100L | . | . | . | . | . | . |
| 6g | 2 | 100L | . | . | . | . | . | . |
| 6h | 5 | . | . | . | . | . | . | . |
| 6i | 3 | . | . | . | . | . | . | . |
| 6j | 3 | . | . | . | . | . | . | . |
| 6k | 8 | 12.5L | . | . | . | . | . | . |
| 6l | 8, 9 | 11.11L | . | . | . | . | . | . |
| 6m | 4 | . | . | . | . | . | . | . |
| 6n | 25 | . | . | . | . | . | . | . |
| 6o | 3 | . | . | . | . | . | . | . |
| 6p | 2 | . | . | . | . | . | . | . |
| 6q | 3 | . | . | . | . | . | . | . |
| 6r | 3 | . | . | . | . | . | 66.7F | . |
| 6s | 3 | 100L | . | . | . | . | 100F | . |
| 6t | 4 | 100L | . | . | . | . | 50F | . |
| 6u | 3 | . | . | . | . | . | . | . |
| 6v | 6 | . | . | . | . | . | . | . |
| 6w | 3 | 100L | . | . | . | . | . | . |
| 6xa | 3 | . | . | . | . | . | 100F | . |
| 6xb | 2 | . | . | . | . | . | . | . |
| 6xc | 1 | . | . | . | . | . | . | . |
| 6xd | 3 | 100L | . | . | . | . | . | 33.3L |
| 6xe | 2 | . | . | . | . | . | . | . |
| 6xf | 2 | 50L | . | . | . | . | . | . |
| 7a | 2 | 100L | . | . | . | . | . | . |
| 7b | 1 | 100L | . | . | 100S | . | . | . |