Table 2.
Prevalence of naturally occurring NS5A RASs in 86 HCV subtypes
| Subtype | No.of seqa | K24 AEGNQRb |
M28 AGIKSTV |
F28CS | L28 AFIMSTV |
Q30 DEGHIKLNRSTY |
R30 CEGHKNQST |
A30 GHKV |
|---|---|---|---|---|---|---|---|---|
| 1a | 2855, 2928 | 0.46R,0.21E,0.32Q | 3.79V, 0.38T,0.10I | n.a. | n.a. | 1.30L, 0.79H, 0.44R | n.a. | n.a. |
| 1b | 1817, 1882 | 1.93K | n.a. | n.a. | 0.11F,2.37M,0.11V | n.a. | 4.66Q,0.59K,0.05H | n.a. |
| 1c | 4 | . | 50V | . | 50M,50V | . | 100Q | . |
| 1d | 1 | . | . | . | . | 100R | . | . |
| 1e | 2 | 50R | . | . | 100M | . | 100Q | . |
| 1g | 2 | 50R | . | . | . | 50.00R | 50.00Q | . |
| 1h | 3 | 100Q | . | . | . | 100R | . | . |
| 1i | 1 | 100Q | . | . | . | 100R | . | . |
| 1j | 1 | . | . | . | 100M | . | 100Q | . |
| 1k | 1 | . | 100A | . | 100A | . | 100Q | . |
| 1l | 3 | 66.67G | . | . | 100M | 33.33R | 66.67Q | . |
| 1m | 2 | . | . | . | 100M | 50S | 50S,50Q | . |
| 1n | 2 | . | . | . | 100M | . | 100Q | . |
| 2a | 52 | . | . | . | 100F | 100K | 100K | 100K |
| 2b | 145 | . | . | . | 4.83F | 99.3K | 99.3K | 99.3K |
| 2c | 9 | . | . | 33.3C | 66.67F | 22.2R,77.8K | 77.8K | 77.8K |
| 2d | 1 | . | . | . | . | 100K | 100K | 100K |
| 2e | 1 | . | . | . | 100F | 100K | 100K | 100K |
| 2f | 2 | 50F | 50S | 50S | 50F,50S | 100K | 100K | 100K |
| 2i | 4 | . | . | . | 100F | 100K | 100K | 100K |
| 2j | 6 | . | . | . | 66.67F | 100K | 100K | 100K |
| 2k | 4 | 25Q | . | . | 25.00F | 25R,75K | 75K | 75K |
| 2l | 2 | . | . | . | . | 100K | 100K | 100K |
| 2m | 4 | . | . | . | . | 50R,50K | 50K | 50K |
| 2q | 2 | . | . | . | . | 100K | 100K | 100K |
| 2r | 1 | . | . | . | 100F | 100K | 100K | 100K |
| 2t | 1 | . | . | . | . | 100K | 100K | 100K |
| 2u | 1 | . | . | . | 100F | 100K | 100K | 100K |
| 3a | 1112, 1114 | 1.08A,0.09T | 0.27V,0.09T | . | 0.09T,99.2M | 1.26L, 0.90T,0.45S | 0.90T,0.45S | 2.25K,0.81V |
| 3b | 19 | . | . | . | 100M | 5.26R,84.2K | 84.2K | 84.2K |
| 3d | 1 | . | . | . | 100M | 100K | 100K | 100K |
| 3e | 1 | . | . | . | 100M | 100K | 100K | 100K |
| 3g | 2 | 50T | . | . | 100M | 100K | 100K | 100K |
| 3h | 2 | . | . | . | 100M | . | . | . |
| 3i | 6 | . | . | . | 100M | 16.67R,83.3K | 83.3K | 83.3K |
| 3k | 2 | 100G | . | . | 50M | 100K | 100K | 100K |
| . | . | . | . | . | . | . | . | . |
| 4a | 30 | . | 6.67V | . | 10M,6.67V | 86.67L,3.33R,3.33H3.33S | 3.33H,3.33S | 3.33H |
| 4b | 2 | . | . | . | . | 50.00S | 50.00S | . |
| 4c | 1 | . | . | . | . | 100R | . | . |
| 4d | 11 | . | . | . | . | 90.91R | . | . |
| 4f | 6 | . | . | . | . | 66.67R | 33.33Q | . |
| 4g | 3 | . | . | . | . | 66.67L,33.33R | . | . |
| 4k | 3 | . | . | . | . | 100R | . | . |
| 4l | 3 | . | . | . | . | 100R | . | . |
| 4m | 4 | . | . | . | . | 100S | 100S | . |
| 4n | 3 | . | . | . | . | 100R | . | . |
| 4o | 4 | . | . | . | 100M | 100T | . | . |
| 4p | 1 | . | . | . | . | 100R | . | . |
| 4q | 1 | . | . | . | . | 100R | . | . |
| 4r | 7 | . | 42.86V,28.6I | . | 28.6I,28.6M,42.7V | 100R | . | . |
| 4s | 1 | . | . | . | . | 100R | . | . |
| 4t | 1 | . | . | . | . | 100R | . | . |
| 4v | 4 | . | . | . | . | 100R | . | . |
| 4w | 2 | . | . | . | 100M | 100S | 100S | . |
| . | . | . | . | . | . | . | . | . |
| 5a | 23 | 100Q | . | . | . | . | 100Q | . |
| 6a | 116 | 89.7Q,6.03R | 2.59V | . | 23.3F,2.59V | 100R | . | . |
| 6b | 2 | . | 100T | . | 100T | 100R | . | . |
| 6c | 2 | . | 100V | . | 100V | 50T | 50T | . |
| 6d | 1 | 100R | 100V | . | 100V | 100T | 100T | . |
| 6e | 13 | 15.38R | 46.15V | . | 53.9M,46.2V | 100S | 100S | . |
| 6f | 18 | . | 61.11T,38.89A | . | 61.1T,38.9A | 100S | 100S | . |
| 6g | 2 | . | . | . | 100M | 50.00S | 50.00S | . |
| 6h | 5 | . | 100V | . | 100V | . | . | . |
| 6i | 3 | . | 66.67V | . | 66.67V | . | . | . |
| 6j | 4 | . | 100V | . | 100V | . | . | . |
| 6k | 8 | 25R | 100V | . | 100V | . | . | . |
| 6l | 7 | . | 100V | . | 100V | . | . | . |
| 6m | 4 | . | 100V | . | 100V | 100S | 100S | . |
| 6n | 9 | . | 100V | . | 100V | 100S | 100S | . |
| 6o | 4 | . | . | . | . | . | . | . |
| 6p | 3 | . | 66.67V | . | 33.3M,66.7V | 100S | 100S | . |
| 6q | 3 | . | 100V | . | 100V | 100S | 100S | . |
| 6r | 3 | . | 33.33G,33.33T | . | 33.33T | . | . | . |
| 6s | 3 | 33.33R | . | . | 33.3M | 100S | 100S | . |
| 6t | 4 | . | 100V | . | 100V | 100S | 100S | . |
| 6u | 2 | . | 100V | . | 100V | 100S | 100S | . |
| 6v | 4 | . | 100V | . | 100V | 100S | 100S | . |
| 6w | 3 | . | 100T | . | 100T | . | . | . |
| 6xa | 3 | . | 100V | . | 100V | 100S | 100S | . |
| 6xb | 2 | . | 100V | . | 100V | . | . | . |
| 6xc | 1 | . | 100V | . | 100V | . | . | . |
| 6xd | 3 | . | . | . | 66.67F | 100R | . | . |
| 6xe | 2 | . | 100V | . | 100V | 100S | 100S | . |
| 6xf | 2 | 50R | 100V | . | 100V | . | . | 50V |
| 7a | 2 | . | . | . | . | 100S | 100S | . |
| 7b | 1 | . | . | . | . | 100S | 100S | . |