Table 3.
Prevalence of naturally occurring NS5B RASs in 86 HCV subtypes
| Sub type | No.of seqa | NS5B NI RAS position | |||||||
|---|---|---|---|---|---|---|---|---|---|
| A150 V |
L159 F |
K206 E |
E237G | S282 TGR |
M289 IL |
L320 F |
V321AI | ||
| 1a | 1433, 5412 | . | 0.09 | 0.12 | 1.54 | 0.19T,0.02G,0.02R | 0.10L | 0.02 | 0.23I,0.02A |
| 1b | 2090, 7462 | 0.08V | 11.2 | 0.03 | 0.06 | 0.15T,0.26R,0.03G | 0.01I | 0.03 | 1.83I,0.01A |
| 1c | 3, 27 | . | . | . | . | . | . | . | . |
| 1d | 1, 27 | . | . | . | . | . | . | . | . |
| 1e | 2, 59 | . | . | . | . | . | . | . | . |
| 1g | 2, 41 | . | . | . | . | . | . | . | 2.7I |
| 1h | 3, 30 | . | . | . | . | . | . | . | . |
| 1i | 1, 6 | . | . | . | . | . | . | . | . |
| 1j | 1, 4 | . | . | . | . | . | . | . | . |
| 1k | 1, 8 | . | . | . | . | . | . | . | 100I |
| 1l | 3, 40 | . | . | . | . | . | . | . | 2.5I |
| 1m | 2, 5 | . | . | . | . | . | . | . | . |
| 1n | 2, 2 | . | . | . | . | . | . | . | 100I |
| 2a | 28, 742 | 13.8 | . | . | . | . | 1.49I, 0.54L | 0.14 | . |
| 2b | 97, 460 | 1.03 | . | . | 3.02 | 0.22T | 7.73I | . | 0.44I |
| 2c | 13, 286 | . | . | . | . | . | 0.35I | . | 0.78I |
| 2d | 1, 9 | . | . | . | . | . | . | . | . |
| 2e | 1, 25 | . | . | . | . | . | 100L | . | . |
| 2f | 2, 14 | . | . | . | . | . | . | . | . |
| 2i | 4, 84 | . | . | . | . | . | 1.19I, 2.38L | . | . |
| 2j | 6, 89 | . | . | 16.7 | 4.76 | . | 1.12I | . | . |
| 2k | 9, 72 | . | . | . | . | . | 1.39I | . | 3.17I |
| 2l | 2, 20 | . | . | . | . | . | 5.00I, 90.0L | . | . |
| 2m | 3, 21 | . | . | . | . | . | . | . | . |
| 2q | 2, 5 | . | . | . | . | . | 20.00I | . | . |
| 2r | 1, 13 | 100 | . | . | . | . | . | . | 46.2I |
| 2t | 1, 1 | . | . | . | . | . | . | . | . |
| 2u | 1, 1 | . | . | . | . | . | . | . | . |
| 3a | 90, 3155 | 31.5 | . | 7.38 | 0.45 | 0.2R,0.03T | 0.07L | 0.03 | 0.13I |
| 3b | 20, 672 | 2.63 | . | 7.92 | 0.67 | 0.15G | . | . | . |
| 3d | 1, 3 | . | . | 100 | . | . | . | . | . |
| 3e | 1, 4 | . | . | . | . | . | . | . | . |
| 3g | 2, 8 | . | . | . | . | . | . | . | . |
| 3h | 2, 12 | . | . | . | . | . | 100L | . | . |
| 3i | 5, 20 | . | . | 33.3 | . | . | . | . | . |
| 3k | 2, 57 | . | . | 55.6 | . | . | . | . | . |
| 4a | 42, 857 | . | . | . | 10.05 | 0.35T,0.12R | 0.95L | 0.12 | 0.12I |
| 4b | 2, 14 | . | . | . | . | . | 7.14L | . | 7.14I |
| 4c | 1, 59 | . | . | . | . | 1.69G | . | . | 3.77I |
| 4d | 25, 672 | . | . | . | 0.95 | 0.18R | 0.18I, 0.18L | . | . |
| 4f | 5, 87 | . | . | . | 2.38 | . | . | . | . |
| 4g | 3, 16 | . | . | . | . | . | . | . | 6.25I |
| 4k | 3, 127 | . | . | . | . | 1.57G | 0.79L | . | 7.14I |
| 4l | 5, 31 | . | . | . | 9.68 | . | 7.69L | . | . |
| 4m | 4, 29 | . | . | 25 | . | . | . | . | . |
| 4n | 2, 31 | . | . | . | 3.23 | . | . | . | . |
| 4o | 4, 44 | . | . | . | . | . | 2.38I | . | . |
| 4p | 1, 16 | . | . | . | . | . | . | . | . |
| 4q | 1, 15 | . | . | . | . | . | 26.7L | . | . |
| 4r | 3, 126 | . | . | . | 1.15 | . | . | . | 60.3I |
| 4s | 1, 3 | . | . | . | . | . | . | . | . |
| 4t | 1, 22 | . | . | . | . | . | . | . | . |
| 4v | 2, 6 | . | . | . | 66.67 | . | 16.7L | . | . |
| 4w | 2, 2 | . | . | . | . | . | . | . | . |
| 5a | 37, 419 | . | . | . | . | . | 1.19I | 0.25 | . |
| 6a | 118, 1290 | . | . | . | . | 0.08R | 1.16L | . | . |
| 6b | 2, 9 | . | . | . | . | . | 77.8L | . | . |
| 6c | 2, 12 | . | . | . | . | . | 100L | . | . |
| 6d | 1, 13 | . | . | . | . | . | 100L | . | . |
| 6e | 16, 139 | . | . | . | . | . | 98.6L | . | . |
| 6f | 5, 121 | . | . | . | . | . | 98.4L | . | 0.87I |
| 6g | 2, 5 | . | . | . | . | . | . | . | . |
| 6h | 5, 42 | . | . | . | . | . | . | . | . |
| 6i | 4, 38 | . | . | . | . | . | . | . | . |
| 6j | 4, 16 | . | . | . | . | . | 50.0L | . | . |
| 6k | 8, 31 | . | . | . | . | . | 100L | . | . |
| 6l | 7, 42 | . | . | 14.3 | . | . | 100L | . | . |
| 6m | 4, 21 | . | . | 87.5 | . | . | . | . | . |
| 6n | 8, 196 | . | . | 6.45 | . | . | 94.9L | . | 0.54I |
| 6o | 4, 13 | . | . | . | . | . | 100L | . | . |
| 6p | 2, 15 | . | . | . | . | . | 6.67I, 93.3L | . | . |
| 6q | 3, 18 | . | . | . | . | . | 100L | . | 16.7I |
| 6r | 3, 11 | . | . | . | . | . | 100L | . | . |
| 6s | 3, 5 | . | . | . | 100 | . | 100L | . | . |
| 6t | 4, 4 | . | . | . | . | . | 100L | . | . |
| 6u | 2, 43 | . | . | . | . | . | 4.65L | . | . |
| 6v | 4, 6 | . | . | . | . | . | . | . | . |
| 6w | 3, 4 | . | . | . | . | . | 100 L | . | . |
| 6xa | 3, 4 | . | . | . | . | . | . | . | . |
| 6xb | 2, 2 | . | . | . | . | . | 100L | . | . |
| 6xc | 1, 1 | . | . | . | . | . | 100L | . | . |
| 6xd | 3, 3 | . | . | . | . | . | 33.3L | . | . |
| 6xe | 2, 2 | . | . | 50 | . | . | 100L | . | . |
| 6xf | 2, 4 | . | . | . | . | . | 100L | . | . |
| 7a | 2, 2 | . | . | . | . | . | . | . | . |
| 7b | 1, 2 | . | . | . | . | . | . | . | . |