Table 3.
(Continued).
| Sub type | NS5B NNI RAS position | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C316 NYHF |
S368T | N411S | M414 TIV |
C445 F |
E446 KQ |
Y448 CH |
A553 ITV |
G554 SD |
S556 GNR |
G558R | D559GN | |
| 1a | 0.02N, 0.09Y | . | . | 0.11T | . | 0.11Q, 0.04K | 0.07H, 0.04C | 0.06V | . | 0.79G,0.34R, 0.11N | 0.42 | . |
| 1b | 43.09N, 0.09Y,1.19H | 0.03 | . | 0.14T, 0.32I,0.03V | 0.67 | 98.46Q | 0.26H, 0.03C | . | 0.09D | 11.77G,0.83N | 0.09 | 0.05N |
| 1c | . | . | . | . | . | . | . | . | . | . | . | . |
| 1d | . | . | . | . | . | 100Q | . | . | . | . | . | . |
| 1e | 10.17N | . | . | . | . | . | . | . | . | . | . | . |
| 1g | 5.26Y, 2.63H | . | . | . | . | 20Q | . | . | . | . | . | . |
| 1h | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 1i | . | . | . | . | . | 100Q | . | . | . | . | . | . |
| 1j | . | . | . | . | . | . | . | . | . | . | . | . |
| 1k | . | . | . | . | . | . | 100H | . | . | . | . | . |
| 1l | 2.50H | . | . | . | . | . | . | . | . | . | . | . |
| 1m | . | . | . | . | . | . | . | . | . | . | . | . |
| 1n | . | . | . | . | . | . | . | . | . | . | . | . |
| 2a | 0.14Y | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 2b | . | . | . | . | 100 | . | . | 95.37V | . | 100G | . | . |
| 2c | . | . | . | . | 100 | . | . | 87.5V, 6.25I | 100S | 100G | . | . |
| 2d | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 2e | . | . | . | . | 100 | . | . | 87.5V | . | 100G | . | . |
| 2f | . | . | . | . | 100 | . | . | 75V 25I |
. | 100G | . | . |
| 2i | . | . | . | . | 100 | . | . | 100 | 100S | 100G | . | . |
| 2j | . | . | . | . | 100 | . | . | 50V, 33.3I, 16.7T | . | 100G | . | . |
| 2k | 3.12H | . | . | . | 90.9 | 9.09Q | . | 88.89V | . | 88.9G | . | . |
| 2l | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 2m | . | . | . | . | 100 | . | . | 100V | 100S | 100G | . | . |
| 2q | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 2r | 7.69N, 7.69Y | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 2t | . | . | . | . | 100 | . | . | 100V | . | . | . | . |
| 2u | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 3a | 0.03Y | . | 0.34 | . | 99.7 | 0.12Q | . | 100V | 1.04S | 97.8G | . | 1.11N |
| 3b | . | . | . | . | 100 | 0.99Q | 0.33H | 100V | . | 100G | . | . |
| 3d | . | . | . | . | 100 | 100Q | . | 100V | . | 100G | . | . |
| 3e | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 3g | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 3h | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 3i | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 3k | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4a | 0.48N | . | . | 91.4V,7.76I | 100 | . | . | 100V | . | 100G | . | . |
| 4b | 14.29N, 7.14H | . | . | 50V | 100 | . | . | 100V | . | 100G | . | . |
| 4c | 5.66Y, 3.77H | . | . | 100I | 100 | . | . | 100V | . | 100G | . | . |
| 4d | 0.16Y | . | . | 2.80T, 96.8I | 100 | . | . | 100V | . | 100G | . | . |
| 4f | 81.61N | . | . | 83.3V,16.7I | 100 | . | . | 100V | . | 100G | . | . |
| 4g | 6.25H | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4k | 0.79Y, 4.76H | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4l | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4m | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4n | 4.35Y | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4o | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4p | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4q | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4r | 60.3H,0.79N | . | . | 9.09I | 100 | . | . | 100V | . | 75N | . | . |
| 4s | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4t | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4v | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 4w | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 5a | . | . | . | . | 98.1 | . | . | 100V | 5.41S | 97.3G | . | . |
| 6a | . | . | . | . | 100 | . | 0.41H | . | . | 0.84R | . | . |
| 6b | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6c | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6d | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6e | 0.72Y | 2.33 | . | . | 98.2 | . | . | . | . | 5.26G,94.7R | . | . |
| 6f | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6g | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6h | . | . | . | . | 100 | . | . | . | . | 85.71G | . | . |
| 6i | . | . | 11.1 | . | 100 | . | . | . | . | . | . | . |
| 6j | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6k | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6l | . | . | . | . | 100 | . | . | . | . | . | . | 10.0G |
| 6m | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6n | . | . | . | 1.16V | 100 | . | 1.16H | . | . | 12.5R | . | . |
| 6o | . | . | . | . | 100 | . | . | 25V | . | 75R | . | . |
| 6p | . | . | . | . | 100 | . | . | 50V | . | 100R | . | . |
| 6q | . | . | . | . | 100 | . | . | . | . | 100R | . | . |
| 6r | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6s | . | . | . | . | 100 | . | . | 100V | . | 100R | . | . |
| 6t | . | . | . | . | 100 | . | . | . | . | 25R | . | . |
| 6u | . | . | . | . | 100 | . | . | . | . | 100R | . | . |
| 6v | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6w | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6xa | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6xb | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6xc | . | . | . | . | 100 | . | . | . | . | 100R | . | . |
| 6xd | . | . | . | . | 100 | . | . | . | . | . | . | 33.3G |
| 6xe | . | . | . | . | 100 | . | . | . | . | . | . | . |
| 6xf | . | . | . | . | 100 | . | . | . | . | 100R | . | . |
| 7a | . | . | . | . | 100 | . | . | 100V | . | 100G | . | . |
| 7b | . | . | . | . | 100 | . | . | . | 100S | 100G | . | . |
Notes: Data are presented as %. The dot denotes 0%. C451S were detected in 1.05% of 1b sequences, G188D in 0.82% of 3a, N224I in 3.06% of 3a and in 3.45% of 6k, A395G in 0.75% of 4a, and Y561H in 0.10% of 1b. L314H, N444K, S565F were not found. aNot all the positions were analyzed using the same number of sequences. The first figure is the lowest number, and the second figure is the largest number.