Figure 4.

DC101 enhances the effects of chemotherapy in preclinical models of (A) synovial sarcoma and (B) DSRCT. All animals were treated with control (●), DC101 (▲), chemotherapy (■; noted in waterfall plot), or the combination (◇). Treatment began at Day 0 and ended at Day 28 (dotted vertical line). For each panel, tumor growth curves are shown on the left and waterfall plots on the right. Error bars represent SEM. Waterfall plots were generated on the day indicated in the top left corner of the image (generally, the last day the majority of vehicle animals were still evaluable). Blue bars: progressive disease (PD; ≥10% ΔT/C). Green bars: stable disease (SD; <10% ΔT/C and <50% regression). Red bars: partial regression (PR; ≥50% regression and tumor volume ≥ 14 mm³). Abbreviations: DSRCT, desmoplastic small round cell tumor; Gem/tax, gemcitabine plus docetaxel.