Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 4;11(17):7187–7196. doi: 10.18632/aging.102244

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

The combination of AZ628 and BP-1-102 showed a strongly synergistic interaction in KRAS-mutant lung cancer cells. Relative viability was measured for KRAS(WT) H838 and KRAS(G12D) H838 cells (A), KRAS(G12S) H292 and KRAS(G12V) H441 cells (B), as well as KRAS(WT) H661and H1650 cells (C) that were treated with the single drug or combined drugs. CI values were calculated for cells treated with a combination of AZ 628 and BP-1-102. CI < 0.7 is considered as synergism; CI = 0.7–0.9 is moderate synergism; CI = 0.90–1.10 is nearly additive; and CI > 1.10 is antagonism.