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. 2019 Sep 4;11(17):7187–7196. doi: 10.18632/aging.102244

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Copyright © 2019 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Combined AZ628 and BP-1-102 blocked MEK/ERK signaling pathway. (A) Western blot determined the protein levels of p-MEK and p-ERK in H838 and KRAS(G12D) cells treated with BP-1-102 alone. (B) Western blot determined the protein levels of p-MEK and p-ERK in KRAS(G12S) H292 and KRAS(G12V) H441 cells, as well as KRAS(WT) H661and H1650 cells treated with BP-1-102 alone. (C) Western blot determined the protein levels of p-MEK and p-ERK in KRAS(WT) H838 and KRAS(G12D) H838 cells treated with AZ628 and BP-1-102combination drugs. (D) Western blot determined the protein levels of p-MEK and p-ERK in KRAS(G12S) H292 and KRAS(G12V) H441 cells treated with AZ628 and BP-1-102combination drugs.