Table 1. Demographics for CN population.
| Variable | CN- | CN+ | Total | p value |
| N | 130 | 113 | 243 | - |
| Age, Mean (SD), years | 72.77 (5.54) | 73.33 (6.21) | 72.76 (6.80) | 0.0510 |
| Female, N (%) | 55 (42.31) | 62 (54.87) | 117 (48.15) | 0.0679 |
| Education, Mean (SD), years | 16.85 (2.64) | 16.35 (2.54) | 16.62 (2.60) | 0.1005 |
| APOEε4, % | 13.85 | 43.36 | 27.57 | <0.0001a |
| ADNI_MEM, Mean (SD) | 1.13 (0.58) | 1.0 (0.59) | 1.07 (0.59) | 0.1052 |
| ADNI_EF, Mean (SD) | 0.95 (0.79) | 0.65 (0.80) | 0.81 (0.81) | 0.0031a |
| CSF Aβ42, Mean (SD), pg/ml | 237.98 (25.62) | 154.732 (32.47) | 199.27 (50.68) | <0.0001a |
| CSF t-tau, Mean (SD), pg/ml | 57.06 (22.67) | 77.47 (39.93) | 66.55 (33.41) | 0.0002a |
| CSF p-tau181, Mean (SD), pg/ml | 26.95 (10.90) | 41.65 (24.66) | 33.79 (19.97) | <0.0001a |
| Hippocampus Volume, Mean (SD), mm3 | 7618.49 (741.95) | 7440.13 (821.38) | 7535.55 (783.34) | 0.0734 |
| FDG-PET | 1.32. (0.11) | 1.30 (0.12) | 1.32 (0.11) | 0.1525 |
| Plasma NFL, Mean (SD), pg/ml | 31.61 (13.10) | 36.39 (14.46) | 33.84 (13.93) | 0.0044a |
| Rate of change Plasma NFL, year | 2.34 | 2.94 | - | <0.0001a |
| Mean (CI), pg/ml | (1.47~3.25) | (1.83~4.04) | - | - |
Abbreviations: APOE, apolipoprotein E; ADNI, Alzheimer’s Disease Neuroimaging Initiative; ADNI_MEM, memory domain composite score; ADNI_EF, executive domain composite score; CSF, cerebrospinal fluid; Aβ, amyloid-β; t-tau, total tau protein; p-tau, phosphorylated tau protein; NFL, neurofilament light chain; SD, standard deviation; CI, confidence interval; CN-, cognitively normal participants with negative Aβ; CN+, cognitively normal participants with positive Aβ
a Lower-case letter indicated that the results were statistically significant.