Table 2. Cross-sectional associations of plasma NFL with CSF biomarkers, cognition and hippocampus volume.

Variable	CN-			CN+			All participants
	β	p value		β	p value		β	p value
CSF Aβ42	-0.0215	0.827		0.02457	0.8109		-0.1421	0.0320a
CSF t-tau	-0.0325	0.741		0.29319	0.0042a		0.1821	0.0091a
CSF p-tau181	-0.0353	0.717		0.095684	0.3604		0.0887	0.2011
FDG-PET	-0.0454	0.6365		-0.09396	0.3821		-0.0811	0.2583
ADNI_MEM	0.0103	0.8375		0.024174	0.6714		0.0098	0.7946
ADNI_EF	0.0634	0.3728		-0.0243	0.7572		-0.0047	0.9311
Hippocampus Volume	-0.0797	0.3178		-0.0336	0.7360		-0.0752	0.2290

Abbreviations: ADNI, Alzheimer’s Disease Neuroimaging Initiative; ADNI_MEM, memory domain composite score; ADNI_EF, executive domain composite score; CSF, cerebrospinal fluid; Aβ, amyloid-β; t-tau, total tau protein; p-tau, phosphorylated tau protein; FDG-PET, F18-fluorodeoxyglucose positron emission tomography; CN-, cognitively normal participants with negative Aβ; CN+, cognitively normal participants with positive Aβ

^a Lower-case letter indicated that the results were statistically significant.

Cross-sectional associations between plasma NFL concentrations and other biomarkers at baseline were tested by multiple linear regression models corrected for age, sex, education and APOE genotype.