Table 2. Risk for all-cause mortality according to B12 quartiles (n=3312).

B12 quartiles (pmol/L)	No. of deceased (%) / alive (%) patients	Model 1 HR (95%CI)	P	Model 2 HR (95%CI)	P	Model 3 HR (95%CI)	P	Model 4 HR (95%CI)	P
Mid-range (260-472) (n=1650)	453 (27%) / 1197 (73%)	Ref.		Ref.		Ref.		Ref.
1st (<259) (n=834)	273 (33%) / 561 (67%)	1.23 (1.06-1.43)	0.007	1.19 (1.02-1.39)	0.024	1.16 (0.99-1.36)	0.071	1.05 (0.88-1.25)	0.592
4th (>473) (n=828)	267 (32%) / 561 (68%)	1.24 (1.06-1.44)	0.006	1.15 (0.99-1.34)	0.074	1.13 (0.96-1.32)	0.148	1.10 (0.92-1.32)	0.278

Model 1: crude model. Model 2: adjusted for sex, LDL-C, HDL-C, BMI, blood pressure, diabetes mellitus, smoking, CAD, MI, stroke, PVD, acute infection, TSH, creatinine, drugs (ACE-inhibitors, lipid lowering therapy, aspirin/other antiplatelet agents, beta blockers, vitamin K antagonist, diuretics, thyroid therapy, vitamin supplementation, Friesinger Score, Gensini Score. Model 3: as model 2 plus age-corrected RTL; Model 4: as 3 plus vitamin B6, folate, HCY, IL-6, hsCRP, albumin, total bilirubin, GOT, GPT, GGT, ALP. Ref.: reference. Significant in bold.