Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Graphical abstract of the senescence pathway in Idh2-deficient conditions. Idh2 deficiency-induced ROS generation accelerates p53 and p21 signaling pathways which inhibit Cdk2 expression. Furthermore, overexpression of Idh2 prevented senescence-associated phenotypes by decreasing the levels of senescence signaling pathway-associated proteins p21 and p53.
