Table 3. Correlation analysis between MLXIPL and PPARGC1A and immune cell infiltrations for ccRCC.
| Description | Gene markers | MLXIPL | PPARGC1A | |||||||||
| None | Purity | None | Purity | |||||||||
| Cor | P | Cor | P | Cor | P | Cor | P | |||||
| CD8+ T cell | CD8A | -0.078 | 0.073 | -0.055 | 0.24 | -0.346 | **** | -0.283 | **** | |||
| CD8B | -0.035 | 0.423 | -0.009 | 0.853 | -0.348 | **** | -0.283 | **** | ||||
| T cell (general) | CD3D | -0.059 | 0.176 | -0.036 | 0.444 | -0.422 | **** | -0.358 | **** | |||
| CD3E | -0.062 | 0.153 | -0.038 | 0.418 | -0.397 | **** | -0.336 | **** | ||||
| CD2 | -0.076 | 0.08 | -0.05 | 0.289 | -0.393 | **** | -0.328 | **** | ||||
| B cell | CD19 | -0.121 | ** | -0.096 | * | -0.325 | **** | -0.257 | **** | |||
| CD79A | -0.155 | *** | -0.143 | ** | -0.362 | **** | -0.309 | **** | ||||
| Monocyte | CD86 | -0.244 | **** | -0.226 | **** | -0.266 | **** | -0.181 | **** | |||
| CD115 (CSF1R) | -0.249 | **** | -0.21 | **** | -0.214 | **** | -0.139 | ** | ||||
| TAM | CCL2 | 0.079 | 0.068 | 0.059 | 0.207 | -0.134 | ** | -0.062 | 0.183 | |||
| CD68 | -0.073 | 0.092 | -0.072 | 0.12 | -0.225 | **** | -0.184 | **** | ||||
| IL10 | -0.236 | **** | -0.189 | **** | -0.24 | **** | -0.167 | *** | ||||
| M1 Macrophage | INOS (NOS2) | -0.034 | 0.436 | -0.023 | 0.629 | 0.048 | 0.264 | 0.088 | 0.059 | |||
| IRF5 | 0.221 | **** | 0.199 | **** | -0.196 | **** | -0.173 | *** | ||||
| COX2 (PTGS2) | -0.284 | **** | -0.268 | **** | -0.083 | 0.054 | -0.04 | 0.39 | ||||
| M2 Macrophage | CD163 | -0.285 | **** | -0.241 | **** | -0.079 | 0.068 | -0.033 | 0.474 | |||
| VSIG4 | -0.294 | **** | -0.249 | **** | -0.237 | **** | -0.183 | **** | ||||
| MS4A4A | -0.285 | **** | -0.243 | **** | -0.208 | **** | -0.146 | ** | ||||
| Neutrophils | CD66b (CEACAM8) | 0.1 | * | 0.09 | 0.053 | 0.073 | 0.094 | 0.051 | 0.276 | |||
| CD11b (ITGAM) | -0.131 | ** | -0.093 | * | -0.167 | *** | -0.094 | * | ||||
| CCR7 | -0.125 | ** | -0.109 | * | -0.307 | **** | -0.236 | **** | ||||
| Natural killer cell | KIR2DL1 | 0.147 | *** | 0.137 | ** | -0.094 | * | -0.1 | * | |||
| KIR2DL3 | 0.108 | * | 0.103 | * | -0.085 | 0.051 | -0.08 | 0.084 | ||||
| KIR2DL4 | 0.028 | 0.512 | 0.033 | 0.475 | -0.284 | **** | -0.267 | **** | ||||
| KIR3DL1 | 0.149 | *** | 0.119 | * | -0.056 | 0.199 | -0.076 | 0.105 | ||||
| KIR3DL2 | 0.133 | ** | 0.094 | * | -0.193 | **** | -0.211 | **** | ||||
| KIR3DL3 | 0.005 | 0.912 | -0.016 | 0.738 | -0.105 | * | -0.081 | 0.082 | ||||
| KIR2DS4 | 0.077 | 0.074 | 0.072 | 0.124 | -0.139 | ** | -0.162 | *** | ||||
| Dendritic cell | HLA-DPB1 | -0.095 | * | -0.062 | 0.184 | -0.28 | **** | -0.213 | **** | |||
| HLA-DQB1 | 0.056 | 0.195 | 0.085 | 0.069 | -0.249 | **** | -0.18 | *** | ||||
| HLA-DRA | -0.143 | *** | -0.114 | * | -0.23 | **** | -0.159 | *** | ||||
| HLA-DPA1 | -0.144 | *** | -0.115 | * | -0.247 | **** | -0.169 | *** | ||||
| BDCA-1 (CD1C) | -0.002 | 0.966 | 0.052 | 0.268 | -0.085 | * | -0.009 | 0.841 | ||||
| BDCA-4 (NRP1) | -0.14 | ** | -0.121 | ** | 0.002 | 0.968 | 0.042 | 0.368 | ||||
| CD11c (ITGAX) | 0.113 | ** | 0.118 | * | -0.207 | **** | -0.165 | *** | ||||
| Th1 | T-bet (TBX21) | 0.106 | * | 0.1 | * | -0.308 | **** | -0.291 | **** | |||
| STAT4 | 0.027 | 0.532 | 0.023 | 0.623 | -0.394 | **** | -0.356 | **** | ||||
| STAT1 | -0.285 | **** | -0.269 | **** | -0.222 | **** | -0.152 | ** | ||||
| IFN-γ (IFNG) | -0.07 | 0.108 | -0.051 | 0.272 | -0.38 | **** | -0.325 | **** | ||||
| TNF-α (TNF) | -0.005 | 0.906 | 0 | 0.998 | -0.177 | **** | -0.132 | ** | ||||
| Th2 | GATA3 | -0.159 | *** | -0.128 | ** | -0.216 | **** | -0.191 | **** | |||
| STAT6 | 0.267 | **** | 0.234 | **** | -0.026 | 0.552 | -0.057 | 0.218 | ||||
| STAT5A | -0.124 | ** | -0.091 | 0.051 | -0.251 | **** | -0.172 | *** | ||||
| IL13 | 0.209 | **** | 0.162 | *** | -0.176 | **** | -0.153 | *** | ||||
| Tfh | BCL6 | -0.011 | 0.804 | -0.052 | 0.262 | -0.13 | ** | -0.156 | *** | |||
| IL21 | -0.131 | ** | -0.122 | ** | -0.104 | * | -0.095 | * | ||||
| Th17 | STAT3 | -0.323 | **** | -0.29 | **** | -0.023 | 0.604 | 0.047 | 0.309 | |||
| IL17A | -0.01 | 0.816 | -0.031 | 0.509 | -0.026 | 0.545 | 0.02 | 0.667 | ||||
| Treg | FOXP3 | -0.08 | 0.064 | -0.064 | 0.168 | -0.422 | **** | -0.346 | **** | |||
| CCR8 | -0.12 | ** | -0.095 | * | -0.271 | **** | -0.184 | **** | ||||
| STAT5B | 0.107 | * | 0.075 | 0.106 | 0.222 | **** | 0.209 | **** | ||||
| TGFβ (TGFB1) | -0.237 | **** | -0.233 | **** | -0.387 | **** | -0.361 | **** | ||||
| T cell exhaustion | PD-1 (PDCD1) | 0.02 | 0.645 | 0.03 | 0.516 | -0.363 | **** | -0.308 | **** | |||
| CTLA4 | -0.006 | 0.894 | 0.003 | 0.949 | -0.309 | **** | -0.23 | **** | ||||
| LAG3 | -0.03 | 0.489 | -0.021 | 0.649 | -0.433 | **** | -0.372 | **** | ||||
| TIM-3 (HAVCR2) | 0.083 | 0.054 | 0.084 | 0.072 | -0.01 | 0.822 | 0.055 | 0.234 | ||||
| GZMB | 0.031 | 0.481 | 0.025 | 0.587 | -0.387 | **** | -0.348 | **** | ||||
TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity.
· p< 0.05; ** p< 0.01; *** p< 0.001; **** p< 0.0001.