Figure 3.

Bar graph shows expression levels of Alzheimer disease (AD) related genes. Ts65Dn (Ts) and disomic (2N) mice were exposed to a maternal choline supplementation (+) or normal diet from conception to weaning and gene expression levels were measured in basal forebrain cholinergic neurons at 4.4–7.5 mos. Multiple AD-associated genes were upregulated in Ts compared with 2N mice including Cav1 and Aplp1, which were downregulated in Ts+ compared with Ts mice. * p < 0.01, ** p < 0.005, mixed effects model with false discovery rate based on null distribution, n = 10 mice per group; a, Ts × 2N; b, Ts+ × Ts; c, 2N+ × 2N; d, Ts+ × 2N+; chromosomes are shown under genes