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In Chinese-hamster-ovary cells, acute (A-D) and chronic (E-J) exposure to enzalutamide (A,C,E,H,I) decreased IKr. Conversely, exposure to dihydrotestosterone (DHT) increased IKr (B,D,G,H,I). A p-value <0.005 was deemed significant to account for multiple comparisons (Bonferroni adjustment; H,I). *p<0.05 vs. control, **p<0.01 vs. control, # p<0.005 vs. enzalutamide (n=5 each)
