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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Stroke. 2019 Aug 9;50(10):2865–2874. doi: 10.1161/STROKEAHA.119.025371

Figure 4. EC-Exo promotes vascular remodeling and increases vessel patency in T2DM-stroke mice.

Figure 4.

(A-B) Stroke in T2DM mice significantly decreases arterial diameter and increases vascular density comapred to non-stroke T2DM control mice. EC-Exo treatment of T2DM-stroke mice significantly increases arterial diameter and vascular density in the cortex and striatum of the IBZ. Loss of miR-126 in EC-Exo attenuates EC-Exo induced vascular remodeling in T2DM-stroke mice. (C) EC-Exo treatment significantly increases vessel patency indicated by increased FITC-dextran vascular perfusion in the cortex, striatum and corpus callosum of the IBZ of T2DM-stroke mice at 14 days after stroke.