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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Gastroenterology. 2019 Jun 5;157(4):1123–1137.e22. doi: 10.1053/j.gastro.2019.06.001

Figure 4. Convergent evolution and heterogeneity in later-occurring driver genes in IPMNs with high-grade dysplasia.

Figure 4.

A-B. Mutations are presented in tables with each row representing a mutation and each column representing a sample. Blue color indicates a mutation call, with variant allele frequencies in each cell of the table. Both depicted IPMNs have multiple mutations called in a later-driver gene. A. IPC16, a high-grade IPMN, has four distinct RNF43 mutations. B. IPC20, a high-grade IPMN, has two different RNF43 mutations and four distinct TP53 mutations. C-D. The 20 IPMNs are represented around the perimeter of the circle in clockwise numerical order – grade of dysplasia/analysis-type for each IPMN is indicated by the colored key. Only heterogeneous mutations are displayed (not all mutations). Each colored rectangle represents a heterogeneous mutation in a given gene, which is indicated by colored key. The heterogeneous mutations in each IPMN are presented by gene in low-grade and whole lesion analysis of high-grade IPMNs (C) and low-grade and high-grade only analysis of high-grade IPMNs (D). Note: Only genes with mutations in at least two IPMNs were included in C-D.