Table 1.
Clinicopathological and molecular data from analyzed IPMNs
| Case | Sex | Age (at surgery)* | Location | Size (cm) | Predominant Histological Subtype | Final Diagnosis | Tissue Analyzed | # of regions | # of samples (LGD,HGD,PDAC) | Mutations Identified | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| IPC01 | F | 80 | Head | 1.6 | Gastric | IPMN with LGD | IPMN | 6 | 6 | (6,0,0) | KRAS(p.G12D, p.G12R, p.G12V, p.GQ60GK), RNF43(p.A169T) |
| IPC02 | M | 50 | Tail | 4.5 | Gastric | IPMN with LGD | IPMN | 8 | 8 | (8,0,0) | KRAS(p.G12D, p.G12R, p.G12V), GNAS(p.R201C, p.R201H), RNF43(p.R286W), TP53(p.P72R) |
| IPC03 | F | 60 | Tail | 2.3 | Gastric | IPMN with LGD | IPMN | 6 | 6 | (6,0,0) | KRAS(p.G12D, p.G12R, p.G12V), GNAS(p.R201H), CDKN2A(p.R80P) |
| IPC04 | M | 70 | Head | 4.2 | Gastric | IPMN with LGD | IPMN | 6 | 6 | (6,0,0) | KRAS(p.G12R), GNAS(p.R201H) |
| IPC05 | F | 80 | Tail | 2.8 | Gastric | IPMN with LGD | IPMN | 8 | 8 | (8,0,0) | KRAS(p.G12V), GNAS(p.R201C) |
| IPC06 | M | 60 | Body | 3 | Gastric | IPMN with LGD | IPMN | 9 | 9 | (9,0,0) | KRAS(p.G12V) GNAS(p.R201C), BRAF(p.N486_P490d el), CTNNB1(p.S45F), TP53(p.L369M) |
| IPC07 | M | 60 | Head | 5 | Gastric | IPMN with LGD | IPMN | 11 | 11 | (11,0,0) | KRAS(p.G12D p.G12V), GNAS(p.R201C), RNF43(p.W15*, p.A115Pfs*43), PIK3CA(p.N1044K) |
| IPC08 | F | 70 | Head | 3 | Gastric | IPMN with LGD | IPMN | 8 | 8 | (8,0,0) | KRAS(p.G12D, p.G12R, p.G12V, p.A146V), GNAS(p.R201C, p.Q227H), RNF43(p.P231L), BRAF(p.N486_P490del), ATM(p.P1526P) |
| IPC09 | M | 80 | Tail | 3 | Intestinal | IPMN with LGD | IPMN | 7 | 7 | (7,0,0) | KRAS(p.G12D, p.G12V), PIK3CA(p.H1047R) |
| IPC10 | M | 70 | Head | 3 | Gastric | IPMN with LGD | IPMN | 6 | 6 | (6,0,0) | KRAS(p.G12D, p.G12V), GNAS(p.R201C, p.R201H), RNF43(p.L418M), STK11(p.P203S) |
| IPC11 | M | 70 | Head | 5 | Pancreatobiliary | IPMN with HGD | IPMN | 10 | 13 | (6,7,0) | KRAS(p.G12V, p.G12S), GNAS(p.R201C, p.R201H, p.Q227E) |
| IPC12 | F | 90 | Head | 5.5 | Intestinal | IPMN with HGD | IPMN | 23 | 25 | (3,22,0) | KRAS(p.A146V, p.Q61H), GNAS(p.R201C, p.Q227H), RNF43(p.Q6Rfs*9), ATM(p.L2475Yfs*2), TP53(p.P72R) |
| IPC13 | M | 70 | Head | 6.5 | Intestinal | IPMN with invasive carcinoma (ductal) | IPMN and carcinoma | 22 | 25 | (0,20,5) | KRAS(p.G12D), GNAS(p.R201H) |
| IPC14 | M | 70 | Head | 2.9 | Intestinal | IPMN with invasive carcinoma (ductal) | IPMN | 11 | 12 | (5,7,0) | KRAS(p.G12R), GNAS(p.R201H), BRAF(p.E26D), ATM(p.L1517F) |
| IPC15 | M | 70 | Head | 3 | Pancreatobiliary | IPMN with HGD | IPMN | 8 | 9 | (5,4,0) | KRAS(p.G12D, p.G12V), GNAS(p.R201C, p.R201S), RNF43(p.E37*) |
| IPC16 | F | 70 | Tail | 2.4 | Intestinal | IPMN with HGD | IPMN | 6 | 10 | (7,3,0) | KRAS(p.G12D), GNAS(p.R201H), RNF43(p.R49Sfs*3, p.R132*, p.Q152*, p.T76Nfs*13) |
| IPC17 | M | 80 | Head | 5 | Intestinal | IPMN with HGD | IPMN | 18 | 19 | (15,4,0) | KRAS(p.A146T, p.Q61H), GNAS(p.R201C), RNF43(p.C119Lfs*6), BRAF(p.T241M), CDKN2A(p.H83N) |
| IPC18 | M | 60 | Head | 4 | Pancreatobiliary | IPMN with HGD | IPMN | 8 | 9 | (1,8,0) | KRAS(p.G12V), RNF43(p.A115Pfs*43, p.S216L) |
| IPC19 | M | 70 | Head | 4 | Intestinal | IPMN with HGD | IPMN | 6 | 6 | (0,6,0) | KRAS(p.G12D), GNAS(p.R201H), RNF43(p.A169T, p.R337*), APC(p.R99W) |
| IPC20 | M | 70 | Head | 2.7 | Intestinal | IPMN with invasive carcinoma (ductal) | IPMN | 24 | 24 | (0,24,0) | KRAS(p.G13D), GNAS(p.R201C), RNF43(p.I141N, p.I201N), TP53(p.V172D, p.P152L, p.D208A, p.R248Q) |
*
To ensure patient privacy, age (at surgery) was rounded in the nearest decade
LGD: low-grade dysplasia; HGD: high-grade dysplasia