. Author manuscript; available in PMC: 2020 Sep 1.

Published in final edited form as: Alzheimers Dement. 2019 Aug 13;15(9):1195–1207. doi: 10.1016/j.jalz.2019.05.012

Table 3.

Odds and Relative Risk ratios (95%CI), p-value, and effect size, of the association of latent class membership with AD pathology among 779 Memory and Aging participants had autopsy results.

	Mixed-Domain Impairment	ES	Memory-Specific Impairment	ES	Frontal Impairment	ES	Superior Cognition	ES
^aAmyloid, %	1.68 (−0.3 – 3.7), 0.095	0.37	1.11 (0.3 – 2.0), 0.010	0.25	−0.07 (−1.1 – 1.0), 0.903	0.02	−1.3 (−2.6 – 0.5), 0.059	0.30
^aTau, mm²	9.1 (5.9 – 12.3), <0.001	1.27	3.75 (2.4 – 5.1), <0.001	0.53	0.63 (−1.1 – 2.4), 0.478	0.11	−1.04 (−3.2 – 1.2), 0.356	0.17
^bGlobal burden of AD pathology low vs very low	0.86 (0.49 – 1.51), 0.594	−0.07	1.15 (0.96 – 1.38), 0.129	0.08	1.04 (0.8 – 1.3), 0.750	0.02	0.58 (0.37 – 0.92), 0.019	−0.22
^bGlobal burden of AD pathology medium/high vs. very low	3.22 (1.7 – 6.0), <0.01	0.36	2.46 (1.55 – 3.90), <0.001	0.25	1.28 (0.6 – 2.6), 0.485	0.06	0.90 (0.37 – 2.20), 0.816	−0.02
^bTDP-43 cytoplasmic inclusions localized to amygdala vs. none	0.74 (0.2 – 2.5), 0.621	−0.10	0.91 (0.6 – 1.3), 0.606	−0.08	0.72 (0.4 – 1.2), 0.186	0.18	0.47 (0.2–1.0), 0.048	0.16
^bTDP-43. cytoplasmic inclusions extended to hippocampus and/or entorhinal cortex vs. none	1.89 (1.1 – 3.1), 0.013	0.27	0.95 (0.7 – 1.4), 0.807	−0.15	0.97 (0.6 – 1.5), 0.876	0.14	0.52 (0.2 – 1.1), 0.096	0.43
^bTDP-43 cytoplasmic inclusions extended to neocortex vs. none	2.69 (1.4 – 5.2), 0.001	0.31	1.74 (1.14 – 2.7), 0.010	0.16	0.80 (0.4 – 1.6), 0.536	0.14	0.73 (0.3 – 1.7), 0.477	0.36
^bHippocampal sclerosis	3.02 (1.2 – 7.4), 0.016	−0.11	2.02 (1.09 – 3.74), 0.026	0.09	0.91 (0.37 – 2.22), 0.828	−0.54	0.54 (0.13 – 2.28), 0.405	−0.07
^bLewy Bodies vs. none	2.07 (1.2 – 3.6), 0.011	0.32	1.42 (1.01 – 1.2), 0.041	−0.31	1.08 (0.7 – 1.7), 0.748	−0.80	1.03 (0.57 – 1.9), 0.921	0.01

Note. Results show postmortem indices of neurodegenerative and cerebrovascular disease pathologies included in the analyses. “Average class” is the control in all models. ES = Effect Size. TDP-43 = transactive response DNA-binding protein 43.

indicates continuous variables: The odds ratios are given; Hedge’s g is computed for effect size.

indicates categorical variables: The relative risk ratios are given, and effect size is calculated using Cohen’s h for binary variables.