Table 2.

Effect of risk factors on baseline biomarker values in total group and by baseline biomarker groups

	Aβ42			T-tau			P-tau
	Mean difference in total group	p-value interaction groups* risk factor	Mean difference per biomarker group	Mean difference in total group	p-value interaction groups* risk factor	Mean difference per biomarker group	Mean difference in total group	p-value interaction groups* risk factor	Mean difference per biomarker group
Hypertension	7.4 ± 61.6	0.603	A−T−: 18.8 ±61.5 A−T+: 220.1 ± 100.7 A+T−: 75.0 ± 80.4 A+T+: −39.3 ±115.9	−6.6 ±9.0	0.675	A−T−: −6.0 ±8.3 A−T+: −11.3 ± 13.6 A+T−: −7.1 ± 10.9 A+T+: −27.2 ± 15.7	−0.9 ± 1.0	0.759	A−T−: −0.7 ±0.9 A−T+: −1.9 ±1.5 A+T−: −0.9 ± 1.2 A+T+: −3.0 ±1.7
Hypercholesterolemia	9.6 ± 194.5	0.603	A−T−: −106.5 ±63.5 A−T+: −164.4 ± 115.9 A+T−: 6.6 ± 79.4 A+T+: 58.3 ± 115.3	−3.5 ±9.1	0.675	A−T−: −4.4 ±8.6 A−T+: −22.9 ± 15.6 A+T−: −15.2 ± 10.7 A+T+: 14.1 ± 15.6	−0.6 ±0.7	0.309	A−T−: −0.4 ±0.9 A−T+: −2.9 ± 1.7 A+T−: −1.7 ±1.2 A+T+: 2.6 ± 1.7
Depression	42.0 ±63.1	0.603	A−T−: 13.6 ±63.3 A−T+: 145.5 ±101.9 A+T−: −76.1 ±83.9 A+T+: −32.7 ± 123.8	−8.4 ±6.3	0.675	A−T−: 2.5 ±8.2 A−T+: −16.8 ± 13.2 A+T−: −15.5 ± 10.9 A+T+: −4.1 ± 16.1	−1.3 ±0.7	0.759	A−T−: .02 ±0.9 A−T+: −2.2 ±1.5 A+T−: −1.6 ±1.2 A+T+: −1.2 ±1.8
Obesity	−180.2 ±275.8	0.603	A−T−: −80.3 ±65.3 A−T+: 169.7 ± 130.6 A+T−: 2.3 ± 82.6 A+T+: −40.4 ± 194.5	−28.0 ±8.9***	0.675	A−T−: −4.2 ±8.7 A−T+: −29.4 ± 17.4 A+T−: −18.0 ± 11.0 A+T+: −60.5 ±26.0	−3.2 ±0.9***	0.309	A−T−: −0.2 ± 1.0 A−T+: −3.4 ±1.9 A+T−: −1.7 ±1.2 A+T+: −7.6 ±2.9*
Cardiovascular disorders	−77.8 ±91.9	0.680	A−T−: −121.0 ± 105.7 A−T+: −176.1 ± 142.8 A+T−: 26.5 ± 128.3 A+T+: −23.4 ± 125.0	−13.4 ± 8.6	0.675	A−T−: −2.7 ± 14.2 A−T+: −17.4 ± 19.2 A+T−: −28.7 ± 17.3 A+T+: −5.0 ± 16.8	−1.4 ± 1.0	0.759	A−T−: −0.4 ± 1.6 A−T+: −1.0 ±2.1 A+T−: −3.0 ±1.9 A+T+: −1.1 ±1.9
Framingham Risk Score	86.0 ±89.1	0.680	A−T−: −98.3 ±80.9 A−T+: −48.0 ± 109.1 A+T−: 51.3 ±93.9 A+T+: −38.4 ± 136.4	−9.2 ±8.8	0.675	A−T−: −12.2 ± 11.2 A−T+: −25.3 ± 15.1 A+T−: −8.5 ± 13.0 A+T+: 9.3 ± 18.8	−0.7 ±0.9	0.759	A−T−: −1.2 ± 1.2 A−T+: −2.0 ± 1.6 A+T−: −0.8 ± 1.4 A+T+: 1.3 ±2.0

Numbers are mean difference ± standard error, between individuals with and without risk factor. Statistical comparisons are conducted on log-transformed Aβ₄₂ values, untransformed values are listed in the table. All analyses are adjusted for age, gender and APOE ε4 status.

^*p<0.05,

^**p<0.01,

^***p<0.001.

Abbreviations: Aβ= amyloid-beta, A= amyloid, T=tau, T-tau = total tau, P-tau = phosphorylated tau₁₈₁.