Table 3.
Effect of risk factors on change in biomarker values over time
| Aβ42 | T-tau | P-tau | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Slope in total group |
p-value interaction group by risk factor |
Slope in biomarker groups |
Slope in total group |
p-value interaction group by risk factor |
Slope in biomarker groups |
Slope in total group |
p-value interaction groups by risk factor |
Slope per biomarker group |
|
| Hypertension | −7.2 ± 11.1 | 0.673 | A−T−: −19.4 ± 15.6 A−T+: 5.7 ± 27.1 A+T−: 11.1 ± 24.9 A+T+: −19.1 ± 36.7 |
3.8 ± 1.7 | 0.012 | A−T−: 0.6 ± 2.3 A−T+: −3.6 ± 4.3 A+T−: 1.8 ± 3.6 A+T+: 21.2 ± 5.2** |
0.4 ± 0.2 | 0.030 | A−T−: 0.1 ± 0.2 A−T+: −0.3 ± 0.4 A+T−: 0.1 ± 0.4 A+T+: 2.1 ± 0.5*** |
| Hypercholesterolemia | −2.6 ± 11.5 | 0.539 | A−T−: −17.2 ± 14.6 A−T+: 70.3 ± 28.3 A+T−: −13.5 ± 23.4 A+T+: 10.6 ± 32.9 |
−2.15 ± 1.8 | 0.844 | A−T−: 0.2 ± 2.5 A−T+: −6.6 ± 4.7 A+T−: −3.9 ± 3.6 A+T+: 2.3 ± 5.0 |
−0.2 ± 0.2 | 0.773 | A−T−: −.02 ± 0.2 A−T+: −0.5 ± 0.4 A+T−: −0.5 ± 0.4 A+T+: 0.1 ± 0.4 |
| Depression | −15.2 ± 11.7 | 0.205 | A−T−: −29.9 ± 15.5 A−T+: 50.4 ± 29.7 A+T−: −3.3 ± 24.6 A+T+: 8.7 ± 43.5 |
−0.15 ± 1.8 | 0.844 | A−T−: −0.1 ± 2.5 A−T+: 5.0 ± 4.6 A+T−: −3.7 ± 3.8 A+T+: 10.6 ± 6.2 |
0.0 ± 0.2 | 0.941 | A−T−: 0.1 ± 0.2 A−T+: 0.5 ± 0.5 A+T−: −0.2 ± 0.4 A+T+: 0.8 ± 0.6 |
| Obesity | 16.5 ± 12.8 | 0.442 | A−T−: 9.837 ± 16.7 A−T+: 31.3 ± 45.8 A+T−: 8.5 ± 24.8 A+T+: −8.6 ± 61.2 |
−3.0 ± 2.0 | 0.880 | A−T−: −2.1 ± 2.7 A−T+: −6.5 ± 6.8 A+T−: 0.6 ± 3.7 A+T+: −8.4 ± 8.9 |
−0.4 ± 0.2 | 0.773 | A−T−: −0.2 ± 0.3 A−T+: −0.7 ± 0.7 A+T−: −0.2 ± 0.4 A+T+: −0.8 ± 0.9 |
| Cardiovascular disorders |
−7.9 ± 20.4 | 0.132 | A−T−: −24.5 ± 29.5 A−T+: −79.2 ± 66.1 A+T−: −3.8 ± 38.2 A+T+: 29.2 ± 44.6 |
0.3 ± 3.0 | 0.844 | A−T−: 0.9 ± 4.8 A−T+: −14.4 ± 8.1 A+T−: −7.4 ± 5.5 A+T+: 4.2 ± 6.0 |
0.1 ± 0.3 | 0.941 | A−T−: 0.2 ± 0.5 A−T+: −1.5 ± 0.8 A+T−: −0.7 ± 0.5 A+T+: 0.2 ± 0.6 |
| Framingham Risk Score |
20.4 ± 15.1 | 0.203 | A−T−: 29.3 ± 21.5 A−T+: 45.0 ± 37.8 A+T−: −15.8 ± 34.4 A+T+: 12.0 ± 55.8 |
4.0 ± 2.1 | 0.063 | A−T−: 0.1 ± 2.8 A−T+: 1.1 ± 4.9 A+T−: 6.7 ± 4.2 A+T+: 17.8 ± 6.9* |
0.3 ± 0.2 | 0.090 | A−T−: .05 ± 0.3 A−T+: 0.1 ± 0.5 A+T−: 0.4 ± 0.4 A+T+: 1.8 ± 0.6 |
Slope (difference risk factor – no risk factor) are mean ± standard error, between individuals with and without risk factors. Statistical comparisons are conducted on log-transformed Aβ42 values. All analyses are adjusted for age, gender and APOE ε4 status.
*
p<0.05,
**
p<0.01,
***
p<0.001.
Abbreviations: Aβ= amyloid-beta, T-tau = total tau, P-tau = phosphorylated tau181.