Table 2.

Cerebral atrophy in moderate-to-severe traumatic brain injury. Effects on the whole brain.

Brain regions	Volume loss	Study types	Number of subjects	References
Global	− 1.51%	Longitudinal: 1 year	Injured: 61 Control: 32	Cole et al.10
	− 8.5%	Longitudinal: 6 months	Injured: 15 Control: 0	Marcoux et al.44
	− 4.5%	Longitudinal: 8 months	Injured: 25 Control: 22	Warner et al.63
	− 4%	Longitudinal: 10 months	Injured: 24 Control: 14	Sidaros et al.52
	–	Cross-sectional	Injured: 22 Control: 27	Gooijers et al.27
Ventricle-to-brain ratio	+1.32% per month	Longitudinal: 20 months	Injured: 56 Control: 12	Green et al.30