Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 23;9:13689. doi: 10.1038/s41598-019-49835-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The effects of pioglitazone (0.3 mg/kg; 1 mg/kg; 3 mg/kg) on histological micrographs of renal tissues. Periodic acid–Schiff (PAS) stain coloring. Original magnification ×20. Figures were randomly chosen from the series of at least 6 experiments (Panels A–G). Panel A: Healthy animal - normal renal parenchyma (PAS staining). Panel B: Animals treated with DMSO only - normal renal parenchyma (PAS staining). Panel C: Animals treated with saline only - normal renal parenchyma (PAS staining). Panel D: Rats subjected to gentamicin-induced nephrotoxicity- marked kidney damage, interstitial edema diffusely present, proximal tubules show loss of brush border and lumen dilatation and loss of nuclei in some epithelial cells. Panel E: Rats subjected to gentamicin induced nephrotoxicity, treated with pioglitazone at dose of 0.3 mg/kg - moderate kidney damage, loss of brush border was observed in half of proximal tubules, in addition to dilatation of lumen and loss of nuclei in some epithelial cells. Panel F: Rats subjected to gentamicin induced nephrotoxicity, treated with pioglitazone at dose of 1 mg/kg –minimal to moderate kidney damage. Panel G: Rats subjected to gentamicin induced nephrotoxicity, treated with pioglitazone at 3 mg/kg – moderate to marked kidney damage, two thirds of proximal tubules show loss of brush border, dilatation of lumen and loss of nuclei in majority of epithelial cells (marked necrosis).