Table 3.
The parameters of oxidative stress recorded in different experimental groups. Each result represents the mean ± SD (n = 4–6).
| Group | PROTEINS | TOS | TAS | OSI | MDA | AOPP | SOD | CAT |
|---|---|---|---|---|---|---|---|---|
| Healthy | 4.55 ± 2.61 | 1.37 ± 0.32 | 0.19 ± 0.04 | 7.02 ± 0.29 | 1.92 ± 0.50 | 6.55 ± 1.60 | 3.74 ± 0.33 | 48.97 ± 6.51 |
| 0.9% NaCl | 5.61 ± 1.26 | 1.23 ± 0.42 | 0.17 ± 0.06 | 7.09 ± 0.31 | 1.92 ± 0.51 | 6.50 ± 1.42 | 3.75 ± 0.32 | 49.00 ± 6.55 |
| DMSO | 8.15 ± 1.14 | 0.40 ± 0.03**†† | 0.19 ± 0.03 | 2.16 ± 0.44 | 0.98 ± 0.21**†† | 3.26 ± 0.04 | 2.84 ± 0.16 | 35.82 ± 2.23 |
| Gentamicin | 7.59 ± 3.18 | 3.15 ± 0.42***†††‡‡‡ | 0.18 ± 0.08 | 21.99 ± 13.88**††‡‡‡#& | 2.65 ± 0.31**††‡‡‡ | 7.15 ± 3.06‡ | 4.74 ± 0.89*†‡‡‡ | 57.48 ± 12.27‡‡ |
| Gentamicin + pioglitazone 0.3 mg/kg | 7.41 ± 4.02 | 2.95 ± 0.22***†††‡‡‡ | 0.23 ± 0.04 | 13.25 ± 3.05 | 2.74 ± 0.08**††‡‡‡ | 6.96 ± 2.40‡ | 4.95 ± 0.26**††‡‡‡ | 46.49 ± 4.85 |
| Gentamicin + pioglitazone 1 mg/kg | 5.90 ± 3.33 | 2.76 ± 0.32***†††‡‡‡ | 0.24 ± 0.03 | 11.37 ± 1.53 | 2.78 ± 0.15**††‡‡‡ | 8.40 ± 0.69‡‡ | 4.26 ± 0.66‡‡ | 52.04 ± 6.90‡ |
| Gentamicin + pioglitazone 3 mg/kg | 7.52 ± 4.19 | 2.49 ± 0.32***†††‡‡‡ | 0.25 ± 0.05 | 10.57 ± 2.80 | 2.67 ± 0.18**††‡‡‡ | 8.19 ± 0.76‡‡ | 4.81 ± 0.40*†‡‡‡ | 59.47 ± 6.18‡‡‡ |
*P < 0.05, **P < 0.01; ***P < 0.001 compared to healthy group (ANOVA followed by Tukey post hoc test);
†P < 0.05, ††P < 0.01; †††P < 0.001 compared to 0.9% NaCl group (ANOVA followed by Tukey post hoc test);
‡P < 0.05, ‡‡P < 0.01, ‡‡‡P < 0.001 compared to DMSO group (ANOVA followed by Tukey post hoc test);
#P < 0.05 compared to GEN + PIO 1 mg/kg (ANOVA followed by Tukey post hoc test);
&P < 0.05 compared to GEN + PIO 3 mg/kg (ANOVA followed by Tukey post hoc test).