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. 2019 Sep 23;9:13677. doi: 10.1038/s41598-019-50216-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SFN and PEITC effectively inhibit growth of model Gram(−) and Gram(+) bacteria, however it is dependent on stringent response in E. coli but not in B. subtilis. Minimal inhibitory concentration (MIC) (A) and zone inhibition (ZI) (A,B) of SFN and PEITC against E. coli and B. subtilis strains and their ppGpp⁰ derivatives. For the zone inhibition test discs were spotted aseptically with 0,1 µg of SFN or PEITC. (C) The synthesis of ppGpp and pppGpp, and level of GTP were assessed by culturing wt or ppGpp-null bacteria in the presence of [³²P]orthophosphoric acid followed by cell lysis and nucleotide separation by thin-layer chromatography. SHX or RHX served as positive controls.