Table 3.
Nephrotoxic drugs most frequently prescribed among exposed patients
| Drugs | n = 617 |
|---|---|
| Iodinated contrast media | 154 (25%) |
| Diuretics | 356 (58%) |
| Loop diuretics | 346 (97%) |
| Thiazide diuretics | 18 (5%) |
| Potassium sparing diuretics | 10 (3%) |
| Antibiotics | 227 (37%) |
| Vancomycin | 77 (34%) |
| Aminoglycosides | 139 (61%) |
| High-dose beta-lactams | 57 (25%) |
| Sulfamethoxazole trimethoprim | 25 (11%) |
| Rifampicin | 12 (5%) |
| Antiviral agents | 58 (9%) |
| Acyclovir | 36 (62%) |
| Other | 22 (38%) |
| Antifungal agents | 27 (4%) |
| Amphotericin B | 9 (33%) |
| Voriconazole | 12 (44%) |
| Other | 6 (22%) |
| Renin–angiotensin–aldosterone antagonists | 96 (16%) |
| Hydroxy-ethyl-starch | 2 (< 0.5%) |
| Mannitol | 5 (< 0.5%) |
| Non-steroidal anti-inflammatory drugs (including acetylsalicylic acid) | 84 (14%) |
| Immunosuppressants and chemotherapy | 16 (3%) |
| Other | 56 (9%) |
Data are presented as counts (percentage). Percentages are calculated among patients receiving at least one nephrotoxic prescription during the first 7 days in the intensive-care unit and within each drug class