Table 1.
The selected demographic and clinical profiles of four lineages and some selected sublineages of L2 and L4.
| L1 | L2 | L2.2.1/Ancestral | Asia Ancestral 2 |
Asia Ancestral 3 |
Ancestral 4 | L2.2.1/Modern | L2.2.1.1 (pacific rd150) | Asian African 2 |
Asian African 3 |
Bmyc22 | Unclassified Modern | L3 | L4 | L4.4 | L4.5.2 | L4.5.3 | TOTAL | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TOTAL patients | 480 | 521 | 265 | 64 | 146 | 40 | 235 | 22 | 68 | 29 | 21 | 93 | 11 | 158 | 38 | 74 | 19 | 1170 |
| Sex: Male | 354 | 357 | 176 | 42 | 103 | 24 | 166 | 16 | 47 | 21 | 17 | 63 | 9 | 110 | 23 | 49 | 18 | 830 |
| Female | 126 | 164 | 89 | 22 | 43 | 16 | 69 | 6 | 21 | 8 | 4 | 30 | 2 | 48 | 15 | 25 | 1 | 340 |
| Average Ages in years (SD) | 51.1 (16.7) | 42.3 (15.9) | 40.9 (15.7) | 39.2 (16) | 41.9 (16.6) | 40.6 (12.2) | 43.6 (16.1) | 44 (16) | 43.1 (14.9) | 44.2 (15.6) | 33.9 (10.8) | 43.3 (16.5) | 41.4 (15.5) | 42.2 (15.2) | 42.8 (16) | 40.6 (15.3) | 46.7 (16.4) | 45.9 (16.7) |
| Median Age in years | 50 | 41 | 39 | 37.5 | 40 | 39 | 42 | 42 | 41.5 | 46 | 31 | 43 | 34 | 41 | 45 | 39) | 44 | 45 |
| (IQR) | (38–65) | (30–52) | (29–51) | (27–52) | (29–52) | (32–50) | (30–54) | (33–52) | (31–53) | 30–51 | 28–43 | (30–53) | (29–49) | (32–52) | (33–54) | (29–52) | (32–52) | (33–58) |
| %with ages > 49 | 51.3 | 31.5 | 30.2 | 31.3 | 30.1 | 32.5 | 31.5 | 27.3 | 27.9 | 31.0 | 9.5 | 50.5 | 18.2 | 29.1 | 28.9 | 31.1 | 36.8 | 39.1 |
| Thai patients | 401 | 282 | 113 | 25 | 70 | 12 | 155 | 21 | 44 | 20 | 11 | 57 | 4 | 66 | 22 | 18 | 10 | 753 |
| RR by Ethnicity | ||||||||||||||||||
| Other Tai ethnic groups |
0.49 (0.32–0.77) |
1.41 (1.08–1.83) |
2.46 (1.68–3.59) |
3.17 (1.36–7.41) |
1.89 (1.03–3.46) |
1.10 | 0.77 | 0 | 1.20 | 0 | 1.20 | 0.93 | 3.30 |
2.20 (1.23–3.93) |
0.60 |
3.67 (1.41–9.52) |
3.96 (1.12–14.0) |
57 |
| Chinese | 0.00 |
2.00 (1.43–2.81) |
2.78 (1.39–5.54) |
2.51 | 2.69 | 0.00 | 1.62 | 0 | 2.85 | 0 | 5.70 | 1.10 | 0 |
2.85 (1.04–7.81) |
2.85 | 3.49 | 6.28 | 12 |
| Burman |
0.31 (0.14–0.70) |
1.87 (1.45–2.40) |
3.11 (2.05–4.73) |
5.02 (2.07–17.1) |
2.51 (1.26–4.98) |
0 | 0.97 | 0 | 1.14 | 0 | 2.28 | 1.32 |
12.55 (2.39–65.9) |
0.76 | 0 | 1.39 | 2.51 | 30 |
| Akha |
0.29 (0.20–0.43) |
1.50 (1.26–1.77) |
2.30 (1.74–3.04) |
1.84 |
1.89 (1.25–2.86) |
6.36 (3.04–13.31) | 0.99 | 0 | 0.81 | 1.02 | 1.86 | 1.35 | 1.28 |
3.16 (2.23–4.47) |
2.10 |
8.25 (4.71–14.46) |
0 | 148 |
| Lahu | 0.18 (0.09–0.36) |
1.67 (1.37–2.04) |
2.58 (1.85–3.59) |
4.02 (2.01–8.04) | 1.72 |
5.02 (1.94–12.99) |
1.10 | 0 | 1.14 | 0.50 | 0.91 | 1.76 | 2.51 | 3.04 (1.96–4.73) | 1.37 |
6.69 (3.35–13.36) |
3.01 | 75 |
| Other Tibeto-Burman family | 0.54 |
1.91 (1.18–3.07) |
3.81 (1.96–7.39) |
4.30 | 3.07 |
8.96 (1.34–59.90) |
0.69 | 0 | 0 | 0 | 0 | 1.89 | 0 | 0 | 0 | 0 | 0 | 7 |
| Hmong-Mien | 0.35 (0.13–0.98) | 1.50 |
2.92 (1.63–5.11) |
1.88 |
2.69 (1.12–6.47) |
7.84 (1.91–32.21) |
0.30 | 0 | 0 | 2.35 | 0 | 0 |
11.77 (1.39–99.47) |
2.14 | 0 |
5.23 (1.32–20.67) |
4.71 | 16 |
| Other ethnic minorities | 0.45 (0.21–0.96) | 1.40 |
2.54 (1.43–4.49) |
5.74 (2.19–15.02) |
1.54 | 2.99 | 0.69 | 0 | 1.63 | 0 | 0 | 0.63 | 0 |
2.71 (1.22–6.04) |
1.63 | 3.98 | 0 | 21 |
| %with HIV | 20.6 | 14.9 | 14.4 | 14.3 | 15.9 | 7.5 | 15.5 | 14.3 | 16.7 | 13.8 | 38.1 | 10.8 | 10 | 14.0 | 16.2 | 6.8 | 21.1 | 17.3 |
| %Resistance | ||||||||||||||||||
| RMP | 2.7 | 6.3 | 4.5 | 1.6 | 4.6 | 0.0 | 7.0 | 5.3 | 12.1 | 21.4 | 0 | 1.1 | 20.0 | 4.6 | 5.4 | 6.9 | 0 | 4.8 |
| INH | 9.5 | 16.2 | 8.3 | 8.2 | 6.9 | 5.7 | 23.3 | 15.8 | 24.2 | 39.3 | 4.8 | 24.2 | 50.0 | 13.7 | 16.2 | 8.3 | 15.8 | 13.5 |
| STM | 3.4 | 15.1 | 7.9 | 11.5 | 6.2 | 8.3 | 22.9 | 15.8 | 21.2 | 57.1 | 0 | 19.8 | 20.0 | 7.2 | 21.6 | 2.8 | 5.3 | 9.3 |
| EMB | 0.5 | 2.5 | 1.2 | 1.6 | 0.8 | 0 | 3.5 | 10.5 | 4.5 | 10.7 | 0 | 0 | 10.0 | 2.0 | 2.7 | 2.8 | 0 | 1.6 |
| % MDR | 2.27 | 4.70 | 2.07 | 0 | 1.54 | 0 | 6.61 | 5.26 | 12.1 | 17.9 | 0 | 1.10 | 20.0 | 3.92 | 5.41 | 5.56 | 0 | 3.75 |
More detailed information is in Supplementary Table S4. SD: standard deviation, IQR: interquartile range, RR: risk ratios, HIV: Human Immunodeficiency Virus, RMP: rifampin, INH: isoniazid, STM: streptomycin, EMB: ethambutol, MDR: resistance to both RMP and INH. Columns displaying the information for the Ancestral and Modern Beijing groups of L2.2.1 are with italized numbers.