Table 4.

Assay conformity based on the kappa statistic

	CSF pNFHa vs CSF NFL	CSF pNFHb vs CSF NFL	CSF pNFHa vs S pNFHa	CSF pNFHb vs S pNFHb	CSF pNFHa vs S pNFHsa	CSF pNFHb vs S pNFHsb
Kappa statistics Conformity (%)	0.380 (80)	0.556 (83)	0.337 (84)	0.306 (71)	0.431 (69)	0.272 (69)
95% CI	0.152‐0.608	0.360‐0.752	0.067‐0.607	0.124‐0.488	0.153‐0.709	0.088‐0.456
Standard error	0.0938	0.1043	0.0938	0.0871	0.1418	0.0940

Positive values were as follows: CSF NFL > 900 ng·L⁻¹ 15; CSF pNFH > 1520^a (respectively, 610^b) ng·L⁻¹; S pNFH > 290¹ (resp., 130^b), ng·L⁻¹ 16.

^a95th percentile for disease controls and healthy.

^b95th percentile for negative samples.