Fig. 8.

SchuS4 lipids and synthetic PEPC2410 liposomes inhibit Dengue virus (DENV)-induced inflammatory cytokines. Human dendritic cells (hDC) (3–4 wells/) were treated with crude SchuS4 lipid (10 µg/mL) or synthetic liposomes comprised of PE24: 0/–10: 0 and PC 24: 0/–24: 0 (PEPC) (20 µg/mL) overnight. Mock-treated cells (Mock) were treated with 5% dextrose in water. hDC were then infected with (MOI = 1) DENV, and supernatants were collected 24 h later for assessment of IL-6 and TNF-α by ELISA (a) and viral load using a plaque assay (b). A–C indicate individual donors. Error bars represent SD.