Fig. 1.

Liver cells expression of innate sensors and related molecules. PHH, LSEC, HSC, KC, LMNC, and PBMC were purified from different donors and cultured for 24 h. RNAs were extracted, and the expression level of 53 mRNAs was assessed by microfluidic high-throughput quantitative RT-PCR (Fluidigm, Biomark) assays. Data are presented as relative expression to two housekeeping genes (RPLP0 and GUS). Black square indicates an absence of expression, nuances of grey a low expression, and nuances of red a higher expression. TLR, toll-like receptor; RLR, retinoic acid inducible gene (RIG)-like receptor; IRF, interferon regulatory factor; NOD, nucleotide-binding oligomerization domain (NOD)-like receptor; CLR, C-type lectin receptor; SOCS, suppressor of cytokine signaling protein; PD-1, programmed cell death one; PD-L1, programmed cell death ligand one; TIM, T-cell immunoglobulin and mucin domain.