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. 2019 Sep 23;4(3):165–176. doi: 10.1089/can.2019.0016

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© Marina Santiago et al. 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 3. — Effect of terpenoids at varying concentrations on AtT20-CB₁ membrane potential and on 1 μM CP55,940-induced hyperpolarization. Terpenoids (A) α-pinene, (B) β-pinene, (C) β-caryophyllene, (D) β-myrcene, (E) linalool, and (F) limonene were added to AtT20-CB₁ cells and incubated for 5 min. Maximum fluorescence changes were not different from negative control (closed circles, n=5, SEM, one-way ANOVA p>0.05). CP55,940 (1 μM) addition to AtT20-CB₁ cells induced fluorescence changes from 33.1%±1.7% to 34.6%±0.7%. Peak CP55,940 responses were not affected by the presence of terpenoids (open circles, n=5, SEM, one-way ANOVA p>0.05). V, vehicle.