Table 3.
Cox proportional hazards models for mortality prediction based on calreticulin levels and severity scores.
| Variable | Univariate Cox model | p value | Multivariate Cox model | p value |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Heart rate | 1.016 (1.000-1.033) | 0.051 | 0.979 (0.957-1.000) | 0.052 |
| Respiration rate | 1.098 (1.038-1.160) | 0.001 | 1.141 (1.057-1.233) | 0.001 |
| MAP | 0.972 (0.951-0.994) | 0.014 | 1.001 (0.974-1.028) | 0.960 |
| PaO2/FiO2 | 0.993 (0.988-0.998) | 0.003 | 0.997 (0.992-1.002) | 0.207 |
| APACHE II score | 1.105 (1.061-1.151) | 0.0001 | 1.070 (1.014-1.129) | 0.013 |
| WBC | 1.042 (1.012-1.073) | 0.006 | 0.904 (0.631-1.296) | 0.584 |
| PMN | 1.052 (1.019-1.086) | 0.002 | 1.194 (0.806-1.769) | 0.377 |
| Lactate | 1.333 (1.194-1.489) | 0.0001 | 1.204 (0.990-1.463) | 0.063 |
| PCT | 1.003 (0.996-1.010) | 0.433 | NA | NA |
| Calreticulin | 1.017 (1.002-1.031) | 0.022 | 1.103 (0.991-1.034) | 0.246 |
p values less than 0.05 were considered statistically significant. APACHE: Acute Physiology and Chronic Health Evaluation; CI: confidence interval; FiO2: inspiratory oxygen fraction; HR: hazard ratio; NA: not applicable; PaO2: arterial oxygen tension; PCT: procalcitonin; WBC: white blood cell; PMN: neutrophil; MAP: mean arterial pressure.