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. 2019 Jul 31;18(4):3646–3654. doi: 10.3892/ol.2019.10691

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — ATRA induces asymmetric cell divisions of GSCs. (A-F) Numb (red) distribution was used to represent GSC division mode in (A-C) vehicle group and (D-F) ATRA group. Cells were counterstained with DAPI (blue) to mark nuclei. White arrows indicate asymmetric pairs. Scale bars, 50 µm. (G) Quantification of the asymmetric cell pairs demonstrated that treatment with ATRA increased the fraction of cell pairs with an asymmetric Numb distribution. *P<0.05. GSC, glioma stem cell; ATRA, all-trans retinoic acid.