Skip to main content
. 2019 Aug 1;18(4):3837–3844. doi: 10.3892/ol.2019.10697

Figure 1.

Figure 1.

miR-873 mediates gemcitabine sensitivity in triple-negative breast cancer cells. (A) Transfection of miR-873 mimics elevated miR-873 level in MDA-MB-231 and BT549 cells. **P<0.01 vs. miR-NC mimics. Overexpression of miR-873 by transfection of miR-873 mimics sensitized (B) MDA-MB-231 cells and (C) BT549 cells towards gemcitabine (0–8 nM). **P<0.01 and ***P<0.0001 vs. miR-NC mimics. (D) Transfection of the miR-873 inhibitor reduced miR-873 levels in MDA-MB-231 and BT549 cells. **P<0.01 and ***P<0.0001 vs. miR-NC inhibitor. Downregulation of miR-873 by transfection of miR-873 inhibitor caused (E) MDA-MB-231 and (F) BT549 cells to become more insensitive towards gemcitabine (0–8 nM). **P<0.01 vs. miR-NC inhibitor. NC, negative control; miR, microRNA.