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. 2019 Sep 12;2019:2324193. doi: 10.1155/2019/2324193

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Copyright © 2019 Aaron L. Slusher et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Ex vivo production of LPS-stimulated PTX3 (a, b) and the senescent-associated inflammatory cytokines following 4- and 24-hour stimulation of isolated PBMCs with LPS, PTX3, and PTX3+LPS in middle-aged and young adults (c–j). In addition, the capacity of PTX3 to produce and alter the LPS-stimulated production of senescent-associated inflammatory cytokines ex vivo was examined. ∗ indicates a significant difference in middle-aged compared to young adults; # indicates a significant difference compared to unstimulated control culture conditions; ¥ indicates a significant difference compared to LPS-stimulated culture conditions; § indicates a significant difference compared to PTX3-stimulated culture conditions (p ≤ 0.05).