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Modulatory mode of miRNA and target mRNA. TRBP recruits the miRNA duplex and Ago2, forming RISC. One strand of miRNA degrades and the other remains, which targets mRNA. There are two ways to silence the target genes: (A) Translative repression by incomplete pairing and (B) degradation of target mRNA by complementary pairing. miRNA, microRNA; TRBP, transactivation response element RNA binding protein; Ago2, argonaute 2; RISC, RNA-induced silencing complex.
