Table I.

Dysregulation of miRNAs associated with oral cancer detected in saliva, blood, serum and plasma.

Author, year	miRNA	Dysregulation	Sample	(Refs.)
Liu et al, 2012	miR-31	Upregulation	Saliva	(28)
Zahran et al, 2015	miR-21	Upregulation	Saliva	(29)
	miR-184	Upregulation	Saliva
Ries et al, 2017	miR-186	Downregulation	Blood	(30)
	miR-3651	Upregulation	Blood
	miR-494	Upregulation	Blood
Yang et al, 2011	miR-181	Upregulation	Plasma	(59)
Wong et al, 2018	miR-184	Upregulation	Plasma	(60)
Lu et al, 2012	miR-10b	Upregulation	Plasma	(61)
	miR-196a	Downregulation	Plasma
	miR-196b	Downregulation	Plasma
	miR-582-5p	Downregulation	Plasma
	miR-15b	Downregulation	Plasma
	miR-301	Downregulation	Plasma
	miR-148b	Downregulation	Plasma
	miR-128a	Downregulation	Plasma
	miR-503	Downregulation	Plasma
	miR-31	Downregulation	Plasma
Kao et al, 2015	miR-21	Upregulation	Plasma	(62)
	miR-31	Upregulation	Plasma
	miR-146	Upregulation	Plasma and saliva
	miR-184	Upregulation	Plasma
	miR-372	Upregulation	Plasma
Liu et al, 2013	miR-196a	Upregulation	Plasma	(63)
Lin et al, 2010	miR-24	Upregulation	Plasma	(64)
Lu et al, 2015	miR-196a	Upregulation	Plasma	(65)
	miR-196b	Upregulation	Plasma
Liu et al, 2017	miR-187*	Upregulation	Plasma	(66)
Lo et al, 2012	miR-27b	Downregulation	Plasma	(67)
Ries et al, 2014	miR-494	Upregulation	Blood	(68)
	miR-3162	Upregulation	Blood
	miR-3651	Upregulation	Blood
	miR-186	Downregulation	Blood
	let-7	Downregulation	Blood

miRNAs associated with oral cancer detected in saliva, blood, serum and plasma may serve as tumor biomarkers. The upregulation of miR-31, miR-494, miR-3651 and miR-196a, and the downregulation of miR-186 are associated with tumor recurrence. High expression levels of miR-181 and miR-196a indicate a poor prognosis. miRNA/miR, microRNA.