Table III.
Tumor-promoting miRNAs and their respective target genes or signaling pathways in oral cancer.
| Author, year | miRNA | Target gene/pathway | Possible role | (Refs.) |
|---|---|---|---|---|
| Zhuang et al, 2017 | miR-218 | PPP2R5A,Wnt (+) | Cisplatin resistance | (112) |
| Jiang et al, 2014 | miR-222 | PUMA | Cisplatin resistance | (113) |
| Du et al, 2017 | miR-221 | TIMP3 | Chemosensitivity | (114) |
| Zhou et al, 2016 | miR-221/222 | PTEN | Proliferation, invasion, apoptosis | (115) |
| Zheng et al, 2015 | miR-24 | PTEN, Akt (+) | Cisplatin resistance | (116) |
| Cheng et al, 2016 | miR-455-5p | UBE2B | Proliferation | (117) |
| Guo et al, 2015 | miR-96 | MTSS1 | Proliferation, metastasis | (118) |
| Hu et al, 2016 | miR-497 | SMAD7 | Metastasis | (119) |
| Kawakubo-Yasukochi et al, 2018 | miR-200c-3p | CHD9, WRN | Invasion | (120) |
| Li et al, 2018 | miR-182-5p | CAMK2N1 | Proliferation | (121) |
| Lin et al, 2016 | miR-187 | BARX2 | Metastasis | (122) |
| Liu et al, 2015 | miR-92b | NLK, NF-κB (+) | Proliferation, apoptosis | (123) |
| Lu et al, 2018 | miR-654-5p | GRAP, Ras-ERK (+) | Metastasis | (124) |
| Peng et al, 2018 | miR-134 | PDCD7 | Proliferation, migration | (125) |
| Qiao et al, 2017 | miR-27a-3p | SFRP1, Wnt/β-catenin (+) | EMT | (126) |
| Zhao et al, 2017 | miR-24 | PTEN | Unknown | (127) |
| Zheng et al, 2016 | miR-21 | CADM1 | Chemosensitivity | (128) |
| Chen et al, 2016 | miR-211 | TCF-12 | Antioxidant activity | (129) |
Οncogenic miRNAs silence their respective target genes, which facilitates cellular proliferation, growth, migration, invasion, metastasis, antioxidant activity and EMT, inhibit apoptosis of cancer cells and reduce chemosensitivity. The (+) symbol indicates activation of downstream signaling pathways. Unknown refers to target genes or possible roles of miRNAs that are not reported in previous studies. miRNA, microRNA; EMT, epithelial-mesenchymal transition; PPP2R5A, protein phosphatase 2 regulatory subunit Bα; TIMP3, tissue inhibitor of metalloproteinase 3; PTEN, phosphatase and tensin homolog; UBE2B, ubiquitin conjugating enzyme E2B; MTSS1, metastasis suppressor 1; SMAD7, SMAD family member 7; CHD9, chromodomain helicase DNA binding protein 9; WRN, Werner syndrome RecQ like helicase; CAMK2N1, calcium/calmodulin-dependent protein kinase II inhibitor 1; BARX2, BarH-like homeobox 2; NLK, nemo-like kinase; GRAP, GRB2-related adaptor protein; PDCD7, programmed cell death 7; SFRP1, secreted frizzled-related protein 1; CADM1, cell adhesion molecule 1; TCF-12, transcription factor 12.