Figure 1.
Altered expression of hematopoietic related factors in BM-MSCsLSC. Although expression of SDF-1 and IL-6 mRNA was downregulated, the expression levels of the other hematopoietic factors (particularly IL-3, IL-7, IL-10 and G-CSF) were upregulated in BM-MSCsLSCs, compared with BM-MSCs. *P<0.05, **P<0.01. BM-MSCs, bone marrow mesenchymal stem cells; LSC, leukemia stem cell; IL, interleukin; SCF, SKP1-CUL1-F protein; G-CSF, granulocyte-colony stimulating factor; LIF, leukemia inhibitory factor; SDF-1, stromal cell-derived factor 1.