Fig. 2. The daily rhythms of blood pressure (BP) and baroreflex sensitivity but not heart rate are disrupted in the db/db-mPer2^Luc mice.

BP and heart rate were recorded by radiotelemetry in the db/db-mPer2^Luc and control db/+-mPer2^Luc mice. a. The 72-hour recording of mean arterial pressure (MAP). The light grey box indicates the dark-phase and the length of the arrowhead lines indicates the BP difference between the light and dark phase in the two mouse strains. b. The 24-hour MAP. c. The 12-hour MAP during the light phase (L) and dark phase (D). d., e. and f.: The amplitude, robustness, and acrophase of the MAP daily oscillation. g. The spontaneous baroreflex sensitivity over the 24-hour day. h. The 72-hour recording of heart rate. i. The 24-hour heart rate. j. The 12-hour heart rate during the light phase (L) and dark phase (D). k., l., and m.: The amplitude, robustness, and acrophase of heart rate daily oscillation. All data were expressed as mean ± SEM (N = 6). *, P < 0.05; **, P < 0.01, ***, P < 0.001; ns, not significant.