Table 1A.
Twenty most up-regulated and twenty most down-regulated canonical pathways after ozone exposure in SHAM, DEMED and ADREX rats (1-D time point).
|
ACTIVATION SCORE |
|||
|---|---|---|---|
| Canonical Pathway | SHAM O3 / SHAM AIR |
DEMED O3 / DEMED AIR |
ADREX O3 / ADREX AIR |
| Ephrin Receptor Signaling | 2.65 | 0.00 | 0.24 |
| ERK5 Signaling | 2.40 | 1.90 | 1.90 |
| Acute Phase Response Signaling | 2.31 | 0.00 | −0.78 |
| VDR/RXR Activation | 2.12 | 0.00 | 0.00 |
| 14–3-3-mediated Signaling | 2.11 | 0.00 | 0.00 |
| PCP pathway | 1.89 | 0.00 | 0.00 |
| Actin Nucleation by ARP-WASP Complex | 1.88 | 0.00 | 0.00 |
| Ceramide Signaling | 1.76 | 0.00 | −1.60 |
| p38 MAPK Signaling | 1.76 | 2.00 | 0.26 |
| CD27 Signaling in Lymphocytes | 1.70 | 0.00 | −1.13 |
| NRF2-mediated Oxidative Stress Response | 1.68 | 0.26 | 0.00 |
| Agrin Interactions at Neuromuscular Junction | 1.63 | 0.00 | 0.00 |
| nNOS Signaling in Neurons | 1.63 | 1.00 | 0.00 |
| Gαi Signaling | 1.46 | 0.00 | 0.00 |
| Apoptosis Signaling | 1.44 | 0.00 | 1.29 |
| Ephrin B Signaling | 1.41 | 0.00 | 0.00 |
| Hypoxia Signaling in the Cardiovascular System | 1.41 | 0.00 | −0.45 |
| PI3K/AKT Signaling | 1.41 | −0.24 | −1.40 |
| Cell Cycle Regulation by BTG Family Proteins | 1.26 | 2.00 | 0.00 |
| PTEN Signaling | 1.26 | 0.00 | 0.24 |
| P2Y Purigenic Receptor Signaling Pathway | −1.95 | 0.00 | 0.26 |
| Macropinocytosis Signaling | −2.00 | 0.00 | 1.26 |
| PEDF Signaling | −2.00 | 0.00 | −0.26 |
| Fc Epsilon RI Signaling | −2.06 | 0.00 | 0.00 |
| Growth Hormone Signaling | −2.12 | 0.00 | 0.90 |
| Role of NFAT in Regulation of the Immune Response | −2.12 | 0.00 | −0.73 |
| IL-9 Signaling | −2.13 | 0.00 | 0.00 |
| Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | −2.14 | 0.00 | −1.21 |
| Role of NFAT in Cardiac Hypertrophy | −2.17 | 0.00 | 0.00 |
| VEGF Family Ligand-Receptor Interactions | −2.20 | 0.00 | 0.28 |
| Type II Diabetes Mellitus Signaling | −2.24 | 0.00 | −0.50 |
| FcγRIIB Signaling in B Lymphocytes | −2.27 | 0.00 | 0.00 |
| TREM1 Signaling | −2.27 | 0.00 | −2.89 |
| Neuropathic Pain Signaling In Dorsal Horn Neurons | −2.29 | 0.00 | 0.00 |
| Glioma Signaling | −2.38 | −0.83 | 0.50 |
| Tec Kinase Signaling | −2.39 | 0.00 | −0.89 |
| ErbB4 Signaling | −2.47 | 0.00 | 0.58 |
| eNOS Signaling | −2.48 | 0.00 | 0.00 |
| NF-κB Activation by Viruses | −2.59 | 0.00 | −1.15 |
| iCOS-iCOSL Signaling in T Helper Cells | −2.92 | 0.00 | −1.21 |
Values indicate the activation score for canonical pathways and were ranked by significant changes determined in SHAM rats. When the p values were not significant the activation score indicated is zero.