Table 1B.

Twenty most up-regulated and twenty most down-regulated canonical pathways after ozone exposure in SHAM and ADREX rats (2-D time point).

	ACTIVATION SCORE
Canonical Pathway	SHAM O3 / SHAM AIR	ADREX O3 / ADREX AIR
LPS/IL-1 Mediated Inhibition of RXR Function	2.18	0
Role of BRCA1 in DNA Damage Response	2.11	0
ERK5 Signaling	1.96	0
Acute Phase Response Signaling	1.62	0
CD27 Signaling in Lymphocytes	1.39	0
Cell Cycle: G1/S Checkpoint Regulation	1.39	0
Ceramide Signaling	1.34	0
Mitotic Roles of Polo-Like Kinase	1.29	0
Ephrin Receptor Signaling	0.85	0
p38 MAPK Signaling	0.76	0
Notch Signaling	0.71	0
CDK5 Signaling	0.69	−0.45
Cdc42 Signaling	0.65	0
p53 Signaling	0.65	0
GNRH Signaling	0.65	0
Rac Signaling	0.60	0
B Cell Receptor Signaling	0.59	0
Toll-like Receptor Signaling	0.53	0
ILK Signaling	0.51	0
TGF-β Signaling	0.45	0
Regulation of Cellular Mechanics by Calpain Protease	−1.73	0
Macropinocytosis Signaling	−1.79	0
PI3K/AKT Signaling	−1.80	0
Growth Hormone Signaling	−1.88	0
iCOS-iCOSL Signaling in T Helper Cells	−1.88	0
IL-2 Signaling	−1.89	0
JAK/Stat Signaling	−1.89	0
eNOS Signaling	−1.98	0
Gαq Signaling	−2.00	0
iNOS Signaling	−2.00	0
Fc Epsilon RI Signaling	−2.12	0
UVA-Induced MAPK Signaling	−2.13	−1.34
mTOR Signaling	−2.19	1
Aryl Hydrocarbon Receptor Signaling	−2.27	0
IL-9 Signaling	−2.31	0
Antiproliferative Role of Somatostatin Receptor 2	−2.32	0
Leukocyte Extravasation Signaling	−2.34	0
Tec Kinase Signaling	−2.40	0
NF-κB Activation by Viruses	−2.45	0
Interferon Signaling	−3.46	0

Values indicate the activation score for canonical pathways and were ranked for significant changes determined in SHAM rats. When the p values were not significant the activation score indicated is zero.