Table 2.
Identification of 10 most predictive targets changed by ozone exposure (1-D) in SHAM, DEMED and ADREX rats using Ingenuity Upstream Regulator Analysis.
|
ACTIVATION SCORE |
|||
|---|---|---|---|
| Predicted Targets | SHAM O3 / SHAM AIR |
DEMED O3 / DEMED AIR |
ADREX O3 / ADREX AIR |
| forskolin | 5.84 | 3.82 | 1.60 |
| methylprednisolone | 4.97 | 1.81 | −0.74 |
| CREB1 | 4.84 | 2.02 | 1.62 |
| PGR | 4.57 | 1.68 | 1.27 |
| XBP1 | 4.54 | 1.23 | −1.86 |
| PDGF BB | 4.51 | 3.40 | 0.78 |
| dexamethasone | 4.51 | 0.03 | 2.35 |
| gentamicin | 4.49 | 2.97 | −0.64 |
| NUPR1 | 4.45 | −1.12 | 1.80 |
| Salmonella enterica serotype abortus equi lipopolysaccharide | 4.41 | 4.07 | 0.00 |
Values indicate the activation score for predicted upstream targets determined by IPA. This analysis is based on the previous knowledge/published database of how known targets act as a transcription regulator considering the direction of change. Values were ranked for the magnitude of the change in SHAM rats and when the p values were not significant or unchanged the activation score indicated is zero