. Author manuscript; available in PMC: 2019 Sep 24.

Published in final edited form as: Toxicol Appl Pharmacol. 2017 Jun 13;329:249–258. doi: 10.1016/j.taap.2017.06.009

Table 3.

Ozone-induced fold change in the expression of glucocorticoid responsive genes in SHAM, DEMED and ADREX rats.

	1-D			2-D

	SHAM Ozone / SHAM Air	DEMED Ozone / DEMED Air	ADREX Ozone / ADREX Air	SHAM Ozone / SHAM Air	ADREX Ozone / ADREX Air
Tsc22d3	2.32^*	1.34	1.16	1.25	0.77

Thbd	1.23	0.92	1.16	1.04	0.98

Sdpr	1.24^*	1.05	1.2^*	0.93	0.92

Slc19a2	1.38^*	1.21	1.25	1.76^*	1.11

Gem	2.73^*	1.80^*	1.10	1.88^*	0.82

Plk2	2.17^*	1.56^*	1.3^*	1.20	0.91

Srgn	1.49^*	1.11	1.03	1.10	1.08

Bhlhe40	2.07^*	1.34	1.32	1.53^*	0.80

Glucocorticoid responsive genes were identified from the master list of ozone-induced differentially expressed genes in the lung. TSC22 domain family protein 3, Tsc22d3 also known as Gilz; thrombomodulin, Thbd; serum deprivation-response protein, Sdpr; thiamine transporter 1, Slc19a2; GTP-binding protein, Gem; serine/threonine-protein kinase PLK2, Plk2; serglycin. Srgn; and class E basic helix-loop-helix protein 40, Bhlhe40. These genes have been shown to be transcriptionally up-regulated after activation of glucocorticoid receptors (Wang et al. 2004). Values indicate mean fold change by ozone when compared to air.

indicate significant ozone effect (adjusted p value<0.05)