Prospective analysis of circulating metabolites and breast cancer in EPIC

. 2019 Sep 24;17:178. doi: 10.1186/s12916-019-1408-4

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Fig. 1 — Odds ratios (ORs) for the associations between metabolites and breast cancer. a Raw P values. b Adjusted P values. PC: phosphatidylcholine; SM: sphingomyelin. ORs are estimated per standard deviation (SD) increase in log-transformed metabolite concentrations, from logistic regression conditioned on matching variables. a Statistical significance based on raw P values (significant metabolites above dotted line). b Statistical significance based on P values adjusted by permutation-based stepdown minP (see “Methods” section for details); adjusted P values above 0.05 (dotted line) were considered statistically significant after correction for multiple tests

Fig. 1.